Physical activity may not be associated with long-term risk of dementia and Alzheimer's disease.
Alzheimer's disease
cohort study
dementia
physical activity
risk factor
Journal
European journal of clinical investigation
ISSN: 1365-2362
Titre abrégé: Eur J Clin Invest
Pays: England
ID NLM: 0245331
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
12
04
2020
revised:
21
08
2020
accepted:
21
09
2020
pubmed:
30
9
2020
medline:
30
11
2021
entrez:
29
9
2020
Statut:
ppublish
Résumé
While it is well established that physical activity is associated with reduced risk of vascular and nonvascular outcomes as well as mortality, evidence on the association between physical activity and dementia is inconsistent. We aimed to assess the associations of physical activity with the risk of dementia and Alzheimer's disease (AD). We analysed data on 2394 apparently healthy men with good baseline cognitive function from the prospective population-based Kuopio Ischaemic Heart Disease study. We assessed habits of physical activity at baseline using a 12-month leisure time physical activity (LTPA) questionnaire. Using Cox regression, we calculated hazard ratios adjusted for body mass index, systolic blood pressure, smoking status, history of type-2 diabetes, total cholesterol, high-density lipoprotein cholesterol, alcohol consumption, history of coronary heart disease and high-sensitivity C-reactive protein. During a median follow-up of 24.9 years (interquartile range: 18.3-26.9), 208 men developed dementia and 128 developed AD. Multivariable adjusted hazard ratios for dementia comparing top vs bottom tertiles of physical activity were 0.97 (95% confidence intervals: 0.69-1.38) for total physical activity volume, 0.96 (0.69-1.34) for conditioning LTPA volume and 1.13 (0.80-1.61) for total LTPA volume. Corresponding hazard ratios for AD were 1.19 (0.76-1.85), 0.98 (0.64-1.49) and 1.22 (0.77-1.93). Associations were consistent in analyses restricted to participants with ≥10 years of follow-up. In middle-aged Caucasian men, various physical activity exposures were not associated with all-cause dementia or AD. Future studies should address biases due to reverse causation and regression dilution and should involve objective measures of physical activity.
Sections du résumé
BACKGROUND
BACKGROUND
While it is well established that physical activity is associated with reduced risk of vascular and nonvascular outcomes as well as mortality, evidence on the association between physical activity and dementia is inconsistent. We aimed to assess the associations of physical activity with the risk of dementia and Alzheimer's disease (AD).
MATERIAL AND METHODS
METHODS
We analysed data on 2394 apparently healthy men with good baseline cognitive function from the prospective population-based Kuopio Ischaemic Heart Disease study. We assessed habits of physical activity at baseline using a 12-month leisure time physical activity (LTPA) questionnaire. Using Cox regression, we calculated hazard ratios adjusted for body mass index, systolic blood pressure, smoking status, history of type-2 diabetes, total cholesterol, high-density lipoprotein cholesterol, alcohol consumption, history of coronary heart disease and high-sensitivity C-reactive protein.
RESULTS
RESULTS
During a median follow-up of 24.9 years (interquartile range: 18.3-26.9), 208 men developed dementia and 128 developed AD. Multivariable adjusted hazard ratios for dementia comparing top vs bottom tertiles of physical activity were 0.97 (95% confidence intervals: 0.69-1.38) for total physical activity volume, 0.96 (0.69-1.34) for conditioning LTPA volume and 1.13 (0.80-1.61) for total LTPA volume. Corresponding hazard ratios for AD were 1.19 (0.76-1.85), 0.98 (0.64-1.49) and 1.22 (0.77-1.93). Associations were consistent in analyses restricted to participants with ≥10 years of follow-up.
CONCLUSIONS
CONCLUSIONS
In middle-aged Caucasian men, various physical activity exposures were not associated with all-cause dementia or AD. Future studies should address biases due to reverse causation and regression dilution and should involve objective measures of physical activity.
Identifiants
pubmed: 32991743
doi: 10.1111/eci.13415
pmc: PMC7988584
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13415Subventions
Organisme : Dr.-Johannes-and Hertha-Tuba Foundation
Organisme : Sydäntutkimussäätiö
Organisme : NIHR Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol
Informations de copyright
© 2020 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.
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