Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks.
Alzheimer Disease
/ genetics
Amyloid Precursor Protein Secretases
/ genetics
Brain
/ metabolism
Calcium
/ metabolism
Calcium Signaling
/ genetics
Cell Membrane
/ genetics
Flavin-Adenine Dinucleotide
/ genetics
Humans
Multiprotein Complexes
/ genetics
Mutant Proteins
/ genetics
Presenilin-1
/ genetics
Presenilin-2
/ genetics
Alzheimer’s disease mouse models
SOCE
autophagy
brain networks
calcium signalling
functional connectivity
mitochondria
oscillations
presenilin-2
slow-waves
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
25 09 2020
25 09 2020
Historique:
received:
31
08
2020
revised:
15
09
2020
accepted:
18
09
2020
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer's disease (FAD). It forms the catalytic core of the γ-secretase complex-a function shared with its homolog presenilin-1 (PS1)-the enzyme ultimately responsible of amyloid-β (Aβ) formation. Besides its enzymatic activity, PS2 is a multifunctional protein, being specifically involved, independently of γ-secretase activity, in the modulation of several cellular processes, such as Ca
Identifiants
pubmed: 32992716
pii: cells9102166
doi: 10.3390/cells9102166
pmc: PMC7601421
pii:
doi:
Substances chimiques
Multiprotein Complexes
0
Mutant Proteins
0
Presenilin-1
0
Presenilin-2
0
Flavin-Adenine Dinucleotide
146-14-5
Amyloid Precursor Protein Secretases
EC 3.4.-
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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