Involvement of Long Non-Coding RNAs (lncRNAs) in Tumor Angiogenesis.
angiogenesis
cancer
long non-coding RNA (lncRNA)
tumor
Journal
Non-coding RNA
ISSN: 2311-553X
Titre abrégé: Noncoding RNA
Pays: Switzerland
ID NLM: 101652294
Informations de publication
Date de publication:
25 Sep 2020
25 Sep 2020
Historique:
received:
31
08
2020
revised:
21
09
2020
accepted:
23
09
2020
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
1
10
2020
Statut:
epublish
Résumé
Long non-coding RNAs (lncRNAs) are defined as non-protein coding transcripts with a minimal length of 200 nucleotides. They are involved in various biological processes such as cell differentiation, apoptosis, as well as in pathophysiological processes. Numerous studies considered that frequently deregulated lncRNAs contribute to all hallmarks of cancer including metastasis, drug resistance, and angiogenesis. Angiogenesis, the formation of new blood vessels, is crucial for a tumor to receive sufficient amounts of nutrients and oxygen and therefore, to grow and exceed in its size over the diameter of 2 mm. In this review, the regulatory mechanisms of lncRNAs are described, which influence tumor angiogenesis by directly or indirectly regulating oncogenic pathways, interacting with other transcripts such as microRNAs (miRNAs) or modulating the tumor microenvironment. Further, angiogenic lncRNAs occurring in several cancer types such as liver, gastrointestinal cancer, or brain tumors are summarized. Growing evidence on the influence of lncRNAs on tumor angiogenesis verified these transcripts as potential predictive or diagnostic biomarkers or therapeutic targets of anti-angiogenesis treatment. However, there are many unsolved questions left which are pointed out in this review, hence driving comprehensive research in this area is necessary to enable an effective use of lncRNAs as either therapeutic molecules or diagnostic targets in cancer.
Identifiants
pubmed: 32992718
pii: ncrna6040042
doi: 10.3390/ncrna6040042
pmc: PMC7711482
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Austrian Science Fund FWF
ID : W 1226
Pays : Austria
Organisme : Austrian Science Fund
ID : DK-MCD W1226
Organisme : Austrian Science Fund
ID : T1112-B
Organisme : Österreichische Gesellschaft für Hämatologie und Onkologie
ID : Forschungsförderung 2019 to Christiane Klec
Organisme : BioTechMed Graz
ID : Lab Rotation Program 2019 to Julia Teppan
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