Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
22
06
2020
accepted:
17
09
2020
pubmed:
1
10
2020
medline:
11
5
2021
entrez:
30
9
2020
Statut:
ppublish
Résumé
Obesity is a major risk factor for insulin resistance (IR) and its attendant complications. The pathogenic mechanisms linking them remain poorly understood, partly due to a lack of intermediary monogenic human phenotypes. Here, we report on a monogenic form of IR-prone obesity, Alström syndrome (ALMS). Twenty-three subjects with monogenic or polygenic obesity underwent hyperinsulinemic-euglycemic clamping with concomitant adipose tissue (AT) microdialysis and an in-depth analysis of subcutaneous AT histology. We have shown a relative AT failure in a monogenic obese cohort, a finding supported by observations in a novel conditional mouse model (
Identifiants
pubmed: 32994277
pii: db20-0647
doi: 10.2337/db20-0647
pmc: PMC7881858
doi:
Banques de données
figshare
['10.2337/figshare.13135370']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
364-376Subventions
Organisme : Medical Research Council
ID : MR/P011462/1
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 by the American Diabetes Association.
Références
Nature. 2012 Apr 19;484(7394):333-8
pubmed: 22466288
Int J Obes (Lond). 2010 Oct;34(10):1554-8
pubmed: 20514046
J Appl Physiol (1985). 2006 Mar;100(3):807-16
pubmed: 16282436
Endocr Rev. 2011 Aug;32(4):498-514
pubmed: 21536711
J Cell Biol. 2015 Mar 2;208(5):501-12
pubmed: 25733711
BMC Endocr Disord. 2018 Nov 26;18(1):88
pubmed: 30477455
Nature. 2008 Jun 5;453(7196):783-7
pubmed: 18454136
N Engl J Med. 2014 Dec 4;371(23):2237-8
pubmed: 25470706
Cell. 2014 Jan 16;156(1-2):20-44
pubmed: 24439368
Metabolites. 2018 Oct 06;8(4):
pubmed: 30301230
Cell. 2008 Sep 19;134(6):933-44
pubmed: 18805087
Int J Mol Med. 2008 Jun;21(6):731-6
pubmed: 18506366
JCI Insight. 2018 Oct 4;3(19):
pubmed: 30282827
PLoS One. 2014 Oct 09;9(10):e109540
pubmed: 25299671
Nat Genet. 2002 May;31(1):74-8
pubmed: 11941369
Diabetes Obes Metab. 2014 Jul;16(7):651-60
pubmed: 24962805
Diabetes. 2010 Nov;59(11):2817-25
pubmed: 20713683
Diabetes. 2005 Jun;54(6):1706-16
pubmed: 15919792
J Clin Endocrinol Metab. 2015 Aug;100(8):E1116-24
pubmed: 26066530
Eur J Med Genet. 2014 Feb;57(2-3):71-5
pubmed: 24462884
Arch Intern Med. 2005 Mar 28;165(6):675-83
pubmed: 15795345
J Clin Invest. 2011 Jun;121(6):2094-101
pubmed: 21633177
J Clin Invest. 2003 Dec;112(12):1821-30
pubmed: 14679177
J Biol Chem. 2003 Sep 5;278(36):33609-12
pubmed: 12788932
J Clin Invest. 2017 Mar 1;127(3):1019-1030
pubmed: 28192375
Nature. 2001 Feb 8;409(6821):729-33
pubmed: 11217863
J Clin Invest. 2019 Oct 1;129(10):3990-4000
pubmed: 31573548
Adv Exp Med Biol. 2017;960:161-196
pubmed: 28585199
J Clin Endocrinol Metab. 2018 Jul 1;103(7):2707-2719
pubmed: 29718281
Minerva Anestesiol. 2013 Nov;79(11):1229-37
pubmed: 23857439
J Clin Endocrinol Metab. 2017 Jul 1;102(7):2443-2453
pubmed: 28419237
Liver Int. 2016 Nov;36(11):1704-1712
pubmed: 27178444
Mol Endocrinol. 2006 Jul;20(7):1610-22
pubmed: 16513793
Biochem Biophys Res Commun. 2006 Apr 21;342(4):1152-9
pubmed: 16516152
J Clin Endocrinol Metab. 2017 Apr 1;102(4):1193-1199
pubmed: 28323973
Nat Rev Endocrinol. 2011 Feb;7(2):77-88
pubmed: 21135875
Diabetes. 1987 Aug;36(8):914-24
pubmed: 3297886
Biochim Biophys Acta. 2010 Mar;1801(3):338-49
pubmed: 20056169
Cell Metab. 2016 May 10;23(5):770-84
pubmed: 27166942