Common genetic variation in humans impacts
SARS-CoV-2
brain, neurons, FURIN rs4702
host genetics
human induced pluripotent stem cell
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
21 Sep 2020
21 Sep 2020
Historique:
pubmed:
1
10
2020
medline:
1
10
2020
entrez:
30
9
2020
Statut:
epublish
Résumé
The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, demonstrates significant inter-individual variability. In addition to showing more disease in males, the elderly, and individuals with underlying comorbidities, SARS-CoV-2 can seemingly render healthy individuals with profound clinical complications. We hypothesize that, in addition to viral load and host antibody repertoire, host genetic variants also impact vulnerability to infection. Here we apply human induced pluripotent stem cell (hiPSC)-based models and CRISPR-engineering to explore the host genetics of SARS-CoV-2. We demonstrate that a single nucleotide polymorphism (rs4702), common in the population at large, and located in the 3'UTR of the protease FURIN, impacts alveolar and neuron infection by SARS-CoV-2
Identifiants
pubmed: 32995783
doi: 10.1101/2020.09.20.300574
pmc: PMC7523109
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIDA NIH HHS
ID : U01 DA048279
Pays : United States
Commentaires et corrections
Type : UpdateIn
Déclaration de conflit d'intérêts
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest.
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