Human diamine oxidase is readily released from activated neutrophils ex vivo and in vivo but is rarely elevated in bacteremic patients.
bacteremia
diamine oxidase
lipopolysaccharide
neutrophil activation
specific granules
Journal
International journal of immunopathology and pharmacology
ISSN: 2058-7384
Titre abrégé: Int J Immunopathol Pharmacol
Pays: England
ID NLM: 8911335
Informations de publication
Date de publication:
Historique:
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
14
7
2021
Statut:
ppublish
Résumé
During human diamine oxidase (DAO) ELISA development we noticed that in serum DAO concentrations appear to be higher when compared to plasma. Neutrophils contain DAO in the specific granules and we hypothesized that DAO is released from neutrophils during serum coagulation. If activation of neutrophils can release DAO, its concentrations might be elevated in vivo after lipopolysaccharide (LPS) administration and in bacteremic patients. Using blood from healthy volunteers DAO concentrations were measured ex vivo in serum, citrate, EDTA and heparin plasma over several hours and after activation of neutrophils. Lipopolysaccharide and granulocyte-colony stimulating factor (G-CSF) were administered to 15 and 8 healthy volunteers, respectively and DAO concentrations were measured at different timepoints. DAO antigen levels were also determined in three different subcohorts of patients with culture-proven bacteremia and high C-reactive protein (CRP) levels. DAO concentrations were elevated in a time-dependent manner in serum but not in EDTA or citrate plasma (
Identifiants
pubmed: 32997559
doi: 10.1177/2058738420954945
pmc: PMC7533923
doi:
Substances chimiques
Biomarkers
0
Lipopolysaccharides
0
Granulocyte Colony-Stimulating Factor
143011-72-7
DAO protein, human
EC 1.4.3.-
D-Amino-Acid Oxidase
EC 1.4.3.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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