Two Sides of the Same Coin: The Roles of KLF6 in Physiology and Pathophysiology.
KLFs
cancer
developmental process
gene regulation
inflammation
transcription factor
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
28 09 2020
28 09 2020
Historique:
received:
07
09
2020
revised:
26
09
2020
accepted:
26
09
2020
entrez:
1
10
2020
pubmed:
2
10
2020
medline:
2
9
2021
Statut:
epublish
Résumé
The Krüppel-like factors (KLFs) family of proteins control several key biological processes that include proliferation, differentiation, metabolism, apoptosis and inflammation. Dysregulation of KLF functions have been shown to disrupt cellular homeostasis and contribute to disease development. KLF6 is a relevant example; a range of functional and expression assays suggested that the dysregulation of KLF6 contributes to the onset of cancer, inflammation-associated diseases as well as cardiovascular diseases. KLF6 expression is either suppressed or elevated depending on the disease, and this is largely due to alternative splicing events producing KLF6 isoforms with specialised functions. Hence, the aim of this review is to discuss the known aspects of KLF6 biology that covers the gene and protein architecture, gene regulation, post-translational modifications and functions of KLF6 in health and diseases. We put special emphasis on the equivocal roles of its full-length and spliced variants. We also deliberate on the therapeutic strategies of KLF6 and its associated signalling pathways. Finally, we provide compelling basic and clinical questions to enhance the knowledge and research on elucidating the roles of KLF6 in physiological and pathophysiological processes.
Identifiants
pubmed: 32998281
pii: biom10101378
doi: 10.3390/biom10101378
pmc: PMC7601070
pii:
doi:
Substances chimiques
Kruppel-Like Factor 6
0
Protein Isoforms
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Universiti Kebangsaan Malaysia
ID : Geran Galakan Penyelidik Muda, GGPM-2020-035.
Pays : International
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