18F-fluoride PET/MR in cardiac amyloid: A comparison study with aortic stenosis and age- and sex-matched controls.
18F-fluoride
Amyloid
Aortic stenosis
CMR
PET
PET/MR
Journal
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
ISSN: 1532-6551
Titre abrégé: J Nucl Cardiol
Pays: United States
ID NLM: 9423534
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
25
05
2020
accepted:
19
08
2020
pubmed:
2
10
2020
medline:
13
4
2022
entrez:
1
10
2020
Statut:
ppublish
Résumé
Cardiac MR is widely used to diagnose cardiac amyloid, but cannot differentiate AL and ATTR subtypes: an important distinction given their differing treatments and prognoses. We used PET/MR imaging to quantify myocardial uptake of 18F-fluoride in ATTR and AL amyloid patients, as well as participants with aortic stenosis and age/sex-matched controls. In this prospective multicenter study, patients were recruited in Edinburgh and New York and underwent 18F-fluoride PET/MR imaging. Standardized volumes of interest were drawn in the septum and areas of late gadolinium enhancement to derive myocardial standardized uptake values (SUV) and tissue-to-background ratio (TBR 53 patients were scanned: 18 with cardiac amyloid (10 ATTR and 8 AL), 13 controls, and 22 with aortic stenosis. No differences in myocardial TBR values were observed between participants scanned in Edinburgh and New York. Mean myocardial TBR Quantitative 18F-fluoride PET/MR imaging can distinguish ATTR amyloid from other similar phenotypes and holds promise in improving the diagnosis of this condition.
Identifiants
pubmed: 33000405
doi: 10.1007/s12350-020-02356-1
pii: 10.1007/s12350-020-02356-1
pmc: PMC8993737
doi:
Substances chimiques
Contrast Media
0
Gadolinium
AU0V1LM3JT
Fluorides
Q80VPU408O
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
741-749Subventions
Organisme : British Heart Foundation
ID : FS/17/19/32641
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL071021
Pays : United States
Organisme : British Heart Foundation
ID : CH/09/002/26360
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : T32 HL007824
Pays : United States
Organisme : Medical Research Council
ID : G0701127
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : KL2 TR001435
Pays : United States
Organisme : British Heart Foundation
ID : FS/16/19/31982
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/16/10/32375
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/17/79/33226
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/14/78/31020
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/17/51/33096
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020. The Author(s).
Références
J Nucl Cardiol. 2021 Feb;28(1):209-218
pubmed: 30834499
J Am Coll Cardiol. 2016 Dec 20;68(24):2712-2714
pubmed: 27978955
J Am Coll Cardiol. 2014 Jul 15;64(2):144-54
pubmed: 25011718
J Nucl Cardiol. 2018 Oct;25(5):1559-1567
pubmed: 28176254
JACC Cardiovasc Imaging. 2016 Mar;9(3):325-7
pubmed: 26189123
J Am Coll Cardiol. 2015 Sep 8;66(10):1200-1
pubmed: 26338001
Eur Heart J. 2017 Oct 07;38(38):2879-2887
pubmed: 29019612
J Am Coll Cardiol. 2010 Jul 20;56(4):278-87
pubmed: 20633819
JACC Cardiovasc Interv. 2012 May;5(5):582-590
pubmed: 22625199
N Engl J Med. 2018 Sep 13;379(11):1007-1016
pubmed: 30145929
J Nucl Cardiol. 2021 Aug;28(4):1586-1595
pubmed: 31512197
J Nucl Med. 1962 Jul;3:332-4
pubmed: 13869926
Circulation. 2016 Jun 14;133(24):2404-12
pubmed: 27143678
Circ Cardiovasc Imaging. 2019 Aug;12(8):e008574
pubmed: 31382765
Nat Commun. 2015 Jul 07;6:7495
pubmed: 26151378
Blood. 2019 Jan 17;133(3):215-223
pubmed: 30333122
Circ Cardiovasc Imaging. 2016 Aug;9(8):
pubmed: 27511979
Ann Intern Med. 2004 Jan 20;140(2):85-93
pubmed: 14734330
Circulation. 2012 Sep 4;126(10):1286-300
pubmed: 22949539
J Am Coll Cardiol. 2017 Jul 25;70(4):466-477
pubmed: 28728692
JACC Cardiovasc Imaging. 2017 Nov;10(11):1320-1333
pubmed: 28017384
Circ Cardiovasc Imaging. 2016 Oct;9(10):
pubmed: 27733431
JACC Cardiovasc Imaging. 2017 Oct;10(10 Pt A):1103-1112
pubmed: 28109921
J Am Coll Cardiol. 2012 Apr 24;59(17):1539-48
pubmed: 22516444
Semin Nucl Med. 1972 Jan;2(1):31-7
pubmed: 5059349
Lancet. 2014 Feb 22;383(9918):705-13
pubmed: 24224999
Br J Haematol. 2020 Feb;188(3):424-427
pubmed: 31515797
JACC Cardiovasc Imaging. 2011 Jun;4(6):659-70
pubmed: 21679902
N Engl J Med. 2003 Aug 7;349(6):583-96
pubmed: 12904524
Phys Med Biol. 2018 Dec 19;64(1):015007
pubmed: 30566409
J Am Coll Cardiol. 2011 Sep 13;58(12):1271-9
pubmed: 21903062