Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies.
breast imaging
early detection
multiscale models
Journal
WIREs mechanisms of disease
ISSN: 2692-9368
Titre abrégé: WIREs Mech Dis
Pays: United States
ID NLM: 9918227353306676
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
revised:
21
08
2020
received:
29
09
2019
accepted:
24
08
2020
pubmed:
2
10
2020
medline:
27
1
2022
entrez:
1
10
2020
Statut:
ppublish
Résumé
Over 90% of breast cancer is cured; yet there remain highly aggressive breast cancers that develop rapidly and are extremely difficult to treat, much less prevent. Breast cancers that rapidly develop between breast image screening are called "interval cancers." The efforts of our team focus on identifying multiscale integrated strategies to identify biologically aggressive precancerous breast lesions. Our goal is to identify spatiotemporal changes that occur prior to development of interval breast cancers. To accomplish this requires integration of new technology. Our team has the ability to perform single cell in situ transcriptional profiling, noncontrast biological imaging, mathematical analysis, and nanoscale evaluation of receptor organization and signaling. These technological innovations allow us to start to identify multidimensional spatial and temporal relationships that drive the transition from biologically aggressive precancer to biologically aggressive interval breast cancer. This article is categorized under: Cancer > Computational Models Cancer > Molecular and Cellular Physiology Cancer > Genetics/Genomics/Epigenetics.
Identifiants
pubmed: 33001587
doi: 10.1002/wsbm.1506
pmc: PMC8544796
mid: NIHMS1646131
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1506Subventions
Organisme : NCI NIH HHS
ID : R01 CA192914
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA189283
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA220693
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA221709
Pays : United States
Organisme : NCI NIH HHS
ID : P20 CA242619
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA170851
Pays : United States
Organisme : NCI NIH HHS
ID : P20 CA242620
Pays : United States
Organisme : NCI NIH HHS
ID : K12 CA001727
Pays : United States
Informations de copyright
© 2020 The Authors. WIREs Systems Biology and Medicine published by Wiley Periodicals LLC.
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