Methods of detection and prevention of preterm labour and the PAMG-1 detection test: a review.
PartoSure
antenatal corticosteroid
cervical length
foetal fibronectin
placental α-microglobulin-1 (PAMG-1)
preterm birth
preterm labour
threatened preterm delivery
Journal
Journal of perinatal medicine
ISSN: 1619-3997
Titre abrégé: J Perinat Med
Pays: Germany
ID NLM: 0361031
Informations de publication
Date de publication:
23 Feb 2021
23 Feb 2021
Historique:
received:
21
06
2020
accepted:
11
09
2020
pubmed:
2
10
2020
medline:
29
10
2021
entrez:
1
10
2020
Statut:
epublish
Résumé
Preterm labour is the leading cause of hospitalization during pregnancy. In France, it results in more than 60,000 births before 37 weeks of gestation every year. Recent studies suggest that detection of placental α-microglobulin-1 (PAMG-1) in vaginal secretions among women presenting symptoms of preterm labour with intact membranes has good predictive value for the onset of spontaneous preterm delivery within 7 days. The test is especially interesting, in that the repetition of antenatal corticosteroids for foetal lung maturation is no longer recommended in France and the effect of the initial administration is most beneficial in the 24 h to 7 days afterwards. We included all studies listed in PubMed and clinicaltrials.gov with the terms "PAMG-1" and either "preterm labor" or "preterm labour", while excluding all studies on the subject of "rupture of the membranes" from 2000 through 2017. Ten studies were thus included. In women who had both the PAMG-1 and foetal fibronectin test, the PAMG-1 test was statistically superior to the measurement of cervical length for positive predictive value (p<0.0074), negative predictive value (p=0.0169) and specificity (p<0.001) for the prediction of spontaneous preterm delivery within 7 days. The use of PAMG-1 may make it possible to target the women at risk with a shortened cervix on ultrasound (<25 mm) those with an imminent preterm delivery and therefore to adapt management, especially the administration of antenatal corticosteroid therapy.
Identifiants
pubmed: 33001855
doi: 10.1515/jpm-2020-0289
pii: jpm-2020-0289
doi:
Substances chimiques
Biomarkers
0
FFN protein, human
0
Fibronectins
0
IGFBP1 protein, human
0
Insulin-Like Growth Factor Binding Protein 1
0
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-126Informations de copyright
© 2020 Walter de Gruyter GmbH, Berlin/Boston.
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