High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite.

Animals Genome Size Host-Parasite Interactions Mass Spectrometry Phylogeny Sarcoptes scabiei / genetics Scabies / parasitology Skin / immunology Swine / parasitology

Journal

PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488

Informations de publication

Date de publication:
10 2020
Historique:
received: 25 02 2020
accepted: 17 08 2020
revised: 27 10 2020
pubmed: 2 10 2020
medline: 23 12 2020
entrez: 1 10 2020
Statut: epublish

Résumé

The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced 'omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolomic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.

Identifiants

DOI: 10.1371/journal.pntd.0008720 PMID: 33001992 PMC: PMC7591027
pubmed: 33001992
doi: 10.1371/journal.pntd.0008720
pii: PNTD-D-20-00286
pmc: PMC7591027
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0008720

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

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Auteurs

Pasi K Korhonen (PK)

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.
ORCID: 0000-0002-9957-4674

Robin B Gasser (RB)

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Guangxu Ma (G)

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Tao Wang (T)

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Andreas J Stroehlein (AJ)

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Neil D Young (ND)

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Ching-Seng Ang (CS)

Bio21 Mass Spectrometry and Proteomics Facility, The University of Melbourne, Melbourne, Victoria, Australia.
ORCID: 0000-0001-7861-6719

Deepani D Fernando (DD)

Cell and Molecular Biology Department, Infectious Diseases Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Hieng C Lu (HC)

Cell and Molecular Biology Department, Infectious Diseases Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0001-7542-2417

Sara Taylor (S)

Cell and Molecular Biology Department, Infectious Diseases Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Simone L Reynolds (SL)

Cell and Molecular Biology Department, Infectious Diseases Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0002-4902-2003

Ehtesham Mofiz (E)

Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
ORCID: 0000-0002-3269-5236

Shivashankar H Najaraj (SH)

Faculty of Health, School-Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.

Harsha Gowda (H)

Cell and Molecular Biology Department, Infectious Diseases Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0002-4118-6855

Anil Madugundu (A)

Institute of Bioinformatics, Bangalore, India.
Center for Individualized Medicine and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America.
Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.

Santosh Renuse (S)

Institute of Bioinformatics, Bangalore, India.

Deborah Holt (D)

Menzies School of Health Research, Charles Darwin University, Darwin, Australia.
College of Health and Human Sciences, Charles Darwin University, Darwin, Australia.
ORCID: 0000-0003-4951-1891

Akhilesh Pandey (A)

Center for Individualized Medicine and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America.

Anthony T Papenfuss (AT)

Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
ORCID: 0000-0002-1102-8506

Katja Fischer (K)

Cell and Molecular Biology Department, Infectious Diseases Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › High-quality nuclear genome for Sarcoptes...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Taille du génome › High-quality nuclear genome for Sarcoptes...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › Interactions hôte-parasite › High-quality nuclear genome for Sarcoptes...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › High-quality nuclear genome for Sarcoptes...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › High-quality nuclear genome for Sarcoptes...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Arachnida › Acari › Mites (acariens) › Sarcoptidae › Sarcopte scabiei › High-quality nuclear genome for Sarcoptes...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Infections de la peau › Dermatoses parasitaires › Gale › High-quality nuclear genome for Sarcoptes...
questionsmedicales.fr › Système tégumentaire › Peau › High-quality nuclear genome for Sarcoptes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › High-quality nuclear genome for Sarcoptes...