No impact of sex and age on beta-adrenoceptor-mediated inotropy in human right atrial trabeculae.
age
human atrial trabeculae
sex
ß-AR-mediated inotropy
ß-adrenoceptors
ß-blocker
Journal
Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
25
06
2020
revised:
30
08
2020
accepted:
22
09
2020
pubmed:
2
10
2020
medline:
19
8
2021
entrez:
1
10
2020
Statut:
ppublish
Résumé
There is an increasing awareness of the impact of age and sex on cardiovascular diseases (CVDs). Differences in physiology are suspected. Beta-adrenoceptors (beta-ARs) are an important drug target in CVD and potential differences might have significant impact on the treatment of many patients. To investigate whether age and sex affects beta-AR function, we analysed a large data set on beta-AR-induced inotropy in human atrial trabeculae. We performed multivariable analysis of individual atrial contractility data from trabeculae obtained during heart surgery of patients in sinus rhythm (535 trabeculae from 165 patients). Noradrenaline or adrenaline were used in the presence of the beta Impact of clinical variables was modelled using multivariable mixed model regression. As previously reported, chronic treatment with beta-blockers sensitized beta-AR. However, there was no significant interaction between basal force, maximum force and beta-AR sensitivity when age and sex were modelled continuously. In addition, there was no statistically significant effect of body mass index or diabetes on atrial contractility. Our large, multivariable analysis shows that neither age nor sex affects beta-AR-mediated inotropy or catecholamine sensitivity in human atrial trabeculae. These findings may have important clinical implications because beta-ARs, as a common drug target in CVD and heart failure, do not behave differently in women and men across age decades.
Substances chimiques
Adrenergic beta-Antagonists
0
Receptors, Adrenergic, beta-2
0
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13564Informations de copyright
© 2020 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.
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