COVID-19 in patients undergoing chronic kidney replacement therapy and kidney transplant recipients in Scotland: findings and experience from the Scottish renal registry.
Betacoronavirus
/ isolation & purification
COVID-19
Communicable Disease Control
/ organization & administration
Comorbidity
Coronavirus Infections
/ diagnosis
Female
Humans
Kidney Failure, Chronic
/ epidemiology
Kidney Transplantation
/ statistics & numerical data
Male
Middle Aged
Mortality
Outcome and Process Assessment, Health Care
Pandemics
/ prevention & control
Pneumonia, Viral
/ diagnosis
Public Health
/ methods
Registries
/ statistics & numerical data
Renal Replacement Therapy
/ methods
SARS-CoV-2
Scotland
/ epidemiology
COVID-19
Epidemiology
Kidney replacement therapy
Registry
Journal
BMC nephrology
ISSN: 1471-2369
Titre abrégé: BMC Nephrol
Pays: England
ID NLM: 100967793
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
13
07
2020
accepted:
09
09
2020
entrez:
2
10
2020
pubmed:
3
10
2020
medline:
21
10
2020
Statut:
epublish
Résumé
Infection with the severe acute respiratory coronavirus 2 (SARS-CoV-2) has led to a worldwide pandemic with coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2, overwhelming healthcare systems globally. Preliminary reports suggest a high incidence of infection and mortality with SARS-CoV-2 in patients receiving kidney replacement therapy (KRT). The aims of this study are to report characteristics, rates and outcomes of all patients affected by infection with SARS-CoV-2 undergoing KRT in Scotland. Study design was an observational cohort study. Data were linked between the Scottish Renal Registry, Health Protection Scotland and the Scottish Intensive Care Society Audit Group national data sets using a unique patient identifier (Community Health Index (CHI)) for each individual by the Public Health and Intelligence unit of Public Health, Scotland. Descriptive statistics and survival analyses were performed. During the period 1st March 2020 to 31st May 2020, 110 patients receiving KRT tested positive for SARS-CoV-2 amounting to 2% of the prevalent KRT population. Of those affected, 86 were receiving haemodialysis or peritoneal dialysis and 24 had a renal transplant. Patients who tested positive were older and more likely to reside in more deprived postcodes. Mortality was high at 26.7% in the dialysis patients and 29.2% in the transplant patients. The rate of detected SARS-CoV-2 in people receiving KRT in Scotland was relatively low but with a high mortality for those demonstrating infection. Although impossible to confirm, it appears that the measures taken within dialysis units coupled with the national shielding policy, have been effective in protecting this population from infection.
Sections du résumé
BACKGROUND
Infection with the severe acute respiratory coronavirus 2 (SARS-CoV-2) has led to a worldwide pandemic with coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2, overwhelming healthcare systems globally. Preliminary reports suggest a high incidence of infection and mortality with SARS-CoV-2 in patients receiving kidney replacement therapy (KRT). The aims of this study are to report characteristics, rates and outcomes of all patients affected by infection with SARS-CoV-2 undergoing KRT in Scotland.
METHODS
Study design was an observational cohort study. Data were linked between the Scottish Renal Registry, Health Protection Scotland and the Scottish Intensive Care Society Audit Group national data sets using a unique patient identifier (Community Health Index (CHI)) for each individual by the Public Health and Intelligence unit of Public Health, Scotland. Descriptive statistics and survival analyses were performed.
RESULTS
During the period 1st March 2020 to 31st May 2020, 110 patients receiving KRT tested positive for SARS-CoV-2 amounting to 2% of the prevalent KRT population. Of those affected, 86 were receiving haemodialysis or peritoneal dialysis and 24 had a renal transplant. Patients who tested positive were older and more likely to reside in more deprived postcodes. Mortality was high at 26.7% in the dialysis patients and 29.2% in the transplant patients.
CONCLUSION
The rate of detected SARS-CoV-2 in people receiving KRT in Scotland was relatively low but with a high mortality for those demonstrating infection. Although impossible to confirm, it appears that the measures taken within dialysis units coupled with the national shielding policy, have been effective in protecting this population from infection.
Identifiants
pubmed: 33004002
doi: 10.1186/s12882-020-02061-8
pii: 10.1186/s12882-020-02061-8
pmc: PMC7528715
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
419Références
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
J Am Soc Nephrol. 2020 Aug;31(8):1815-1823
pubmed: 32561681
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
N Engl J Med. 2020 Sep 3;383(10):994
pubmed: 32649078
N Engl J Med. 2020 Jun 18;382(25):2475-2477
pubmed: 32329975
Nat Rev Nephrol. 2020 Jun;16(6):311-313
pubmed: 32249840
Kidney Int. 2020 Jul;98(1):12-16
pubmed: 32471637
Blood Purif. 2020;49(3):259-264
pubmed: 32235119
J Am Soc Nephrol. 2020 Jul;31(7):1409-1415
pubmed: 32467113
Am J Kidney Dis. 2020 Jul;76(1):141-143
pubmed: 32240718
Clin J Am Soc Nephrol. 2008 Sep;3(5):1526-33
pubmed: 18701615
BMJ. 2020 May 22;369:m1985
pubmed: 32444460
Nefrologia (Engl Ed). 2020 May - Jun;40(3):272-278
pubmed: 32389518
Nature. 2020 Aug;584(7821):430-436
pubmed: 32640463
Clin J Am Soc Nephrol. 2020 Aug 7;15(8):1139-1145
pubmed: 32444393
Nephrol Dial Transplant. 2020 May 1;35(5):737-741
pubmed: 32196116
Kidney Int. 2020 Jul;98(1):20-26
pubmed: 32437768
J Am Soc Nephrol. 2020 Jul;31(7):1398-1408
pubmed: 32482688
Kidney Int. 2020 Jul;98(1):27-34
pubmed: 32437770