Renal fibrosis detected by diffusion-weighted magnetic resonance imaging remains unchanged despite treatment in subjects with renovascular disease.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
03
04
2020
accepted:
11
09
2020
entrez:
2
10
2020
pubmed:
3
10
2020
medline:
5
1
2021
Statut:
epublish
Résumé
Tissue fibrosis is an important index of renal disease progression. Diffusion-weighted magnetic resonance imaging's (DWI-MRI) apparent diffusion coefficient (ADC) reveals water diffusion is unobstructed by microstructural alterations like fibrosis. We hypothesized that ADC may indicate renal injury and response to therapy in patients with renovascular disease (RVD). RVD patients were treated with medical therapy (MT) and percutaneous transluminal renal angioplasty (MT + PTRA) (n = 11, 3 bilaterally, n = 14 kidneys) or MT (n = 9). ADC and renal hypoxia (R2*) by blood-oxygen-level-dependent MRI were studied before (n = 27) and 3 months after (n = 20) treatment. Twelve patients underwent renal biopsies. Baseline ADC values were correlated with changes in eGFR, serum creatinine (SCr), systolic blood pressure (SBP), renal hypoxia, and renal vein levels of pro-inflammatory marker tumor necrosis-factor (TNF)-α. Renal oxygenation, eGFR, and SCr improved after MT + PTRA. ADC inversely correlated with the histological degree of renal fibrosis, but remained unchanged after MT or MT + PTRA. Basal ADC values correlated modestly with change in SBP, but not in renal hypoxia, TNF-α levels, or renal function. Lower ADC potentially reflects renal injury in RVD patients, but does not change in response to medical or interventional therapy over 3 months. Future studies need to pinpoint indices of kidney recovery potential.
Identifiants
pubmed: 33004888
doi: 10.1038/s41598-020-73202-0
pii: 10.1038/s41598-020-73202-0
pmc: PMC7530710
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16300Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK122734
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100081
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK104273
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG062104
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120292
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK100081
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK104273
Pays : United States
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