Clear cell sarcoma-like/malignant gastrointestinal neuroectodermal tumor of the tongue: a clinicopathologic and molecular case report.
Clear cell sarcoma
Malignant gastrointestinal neuroectodermal tumor
Next-generation sequencing
Oral cavity
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
12
06
2020
accepted:
15
09
2020
revised:
07
09
2020
pubmed:
3
10
2020
medline:
29
6
2021
entrez:
2
10
2020
Statut:
ppublish
Résumé
Malignant gastrointestinal neuroectodermal tumor (M-GNET) and clear cell sarcoma (CCS) of soft tissue represent closely related, extremely rare, malignant mesenchymal neoplasm of uncertain differentiation. Both entities are characterized genetically by the same molecular alterations represented by the presence of EWSR1-ATF1 and, more rarely, EWSR1-CREB1 fusion genes. The latter translocation seems to be more represented in M-GNET that, despite significant morphologic overlap with CCS, tends to lack overt features of melanocytic differentiation. Most M-GNET occur in the lower gastrointestinal tract, whereas occurrence in the upper tract has been reported only exceptionally. The differential diagnosis represents a major challenge, and accurate diagnosis impact significantly on therapeutic planning. We herein report the clinicopathologic features of a molecularly confirmed M-GNET that arose at the base of the tongue and review the pertinent literature.
Identifiants
pubmed: 33005982
doi: 10.1007/s00428-020-02933-2
pii: 10.1007/s00428-020-02933-2
doi:
Substances chimiques
Biomarkers, Tumor
0
Calmodulin-Binding Proteins
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1203-1207Références
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