Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks.

Animals Basic Helix-Loop-Helix Transcription Factors / genetics Female Male Maxillofacial Development / genetics Mice / genetics Models, Animal Nerve Tissue Proteins / genetics Skull / growth & development Zinc Finger Protein Gli3 / genetics
Gli transcription factors Hand2 cis-regulatory modules developmental biology functional genomic low affinity binding mandible mouse

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
02 10 2020
Historique:
received: 27 02 2020
accepted: 01 10 2020
pubmed: 3 10 2020
medline: 24 2 2021
entrez: 2 10 2020
Statut: epublish

Résumé

Despite a common understanding that Gli TFs are utilized to convey a Hh morphogen gradient, genetic analyses suggest craniofacial development does not completely fit this paradigm. Using the mouse model (

Identifiants

DOI: 10.7554/eLife.56450 PMID: 33006313 PMC: PMC7556880
pubmed: 33006313
doi: 10.7554/eLife.56450
pii: 56450
pmc: PMC7556880
doi:
pii:

Substances chimiques

Basic Helix-Loop-Helix Transcription Factors 0
Gli3 protein, mouse 0
Hand2 protein, mouse 0
Nerve Tissue Proteins 0
Zinc Finger Protein Gli3 0

Banques de données

GEO
['GSE141431', 'GSE141173', 'GSE146961', 'GSE55707']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDCR NIH HHS
ID : R35 DE027557
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM063483
Pays : United States
Organisme : NIDCR NIH HHS
ID : F31 DE027872
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM124251
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM079428
Pays : United States

Informations de copyright

© 2020, Elliott et al.

Déclaration de conflit d'intérêts

KE, XC, JS, PC, PS, SB, JS, AZ, RZ, BG, MW, KP, SB No competing interests declared

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Auteurs

Kelsey H Elliott (KH)

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Division of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Graduate Program in Molecular and Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, United States.

Xiaoting Chen (X)

Center for Autoimmune Genomics and Etiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.

Joseph Salomone (J)

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Graduate Program in Molecular and Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, United States.
Medical-Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, United States.

Praneet Chaturvedi (P)

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.

Preston A Schultz (PA)

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Division of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.

Sai K Balchand (SK)

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Division of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.

Jeffrey D Servetas (JD)

Jackson Laboratory, Bar Harbor, United States.

Aimée Zuniga (A)

Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.

Rolf Zeller (R)

Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.

Brian Gebelein (B)

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
ORCID: 0000-0001-9791-9061

Matthew T Weirauch (MT)

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Center for Autoimmune Genomics and Etiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.

Kevin A Peterson (KA)

Jackson Laboratory, Bar Harbor, United States.

Samantha A Brugmann (SA)

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Division of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Shriners Children's Hospital, Cincinnati, United States.
ORCID: 0000-0002-6860-6450

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Gli3 utilizes Hand2 to synergistically...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Gli3 utilizes Hand2 to synergistically...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Développement maxillofacial › Gli3 utilizes Hand2 to synergistically...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Gli3 utilizes Hand2 to synergistically...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Gli3 utilizes Hand2 to synergistically...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Gli3 utilizes Hand2 to synergistically...
questionsmedicales.fr › Appareil locomoteur › Squelette › Crâne › Gli3 utilizes Hand2 to synergistically...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Protéine à doigts de zinc Gli3 › Gli3 utilizes Hand2 to synergistically...