CFD-DEM -DDM Model for Spray Coating Process in a Wurster Coater.
CFD-DEM
Fluidized bed
Simulation
Spray coating
Journal
Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
01
06
2020
revised:
30
07
2020
accepted:
21
09
2020
pubmed:
3
10
2020
medline:
2
12
2020
entrez:
2
10
2020
Statut:
ppublish
Résumé
A multiscale model by coupling computational fluid dynamics (CFD) with a discrete element model (DEM) and discrete droplet model (DDM) is developed to simulate a lab-scale Wurster coater. Two case studies are conducted to study the effect of particle shape in the system. In the first case study, 45,000 spherical particles are coated for 5 s while for the second case study, a mixture of 22,500 spherical particles and 22,500 cylindrical particles is simulated. The residence time distributions (RTD) of particles in different spray zones are compared, and the best spray zone is derived by analysing the positions of spray droplet-particle contacts. The simulation results show that the RTD of the particles within an accurate spray zone can provide valuable information on the final product's particles size distribution. Furthermore, the coefficient of variation (COV) for the coating mass received by the particles is studied for both case studies.
Identifiants
pubmed: 33007276
pii: S0022-3549(20)30562-1
doi: 10.1016/j.xphs.2020.09.032
pii:
doi:
Substances chimiques
Powders
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3678-3689Informations de copyright
Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.