Mycotoxins: Biotransformation and Bioavailability Assessment Using Caco-2 Cell Monolayer.
bioavailability
biotransformation
cytochrome
intestinal transport
metabolism
mycotoxins
permeability
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
30 09 2020
30 09 2020
Historique:
received:
12
06
2020
revised:
24
08
2020
accepted:
18
09
2020
entrez:
3
10
2020
pubmed:
4
10
2020
medline:
17
6
2021
Statut:
epublish
Résumé
The determination of mycotoxins content in food is not sufficient for the prediction of their potential in vivo cytotoxicity because it does not reflect their bioavailability and mutual interactions within complex matrices, which may significantly alter the toxic effects. Moreover, many mycotoxins undergo biotransformation and metabolization during the intestinal absorption process. Biotransformation is predominantly the conversion of mycotoxins meditated by cytochrome P450 and other enzymes. This should transform the toxins to nontoxic metabolites but it may possibly result in unexpectedly high toxicity. Therefore, the verification of biotransformation and bioavailability provides valuable information to correctly interpret occurrence data and biomonitoring results. Among all of the methods available, the in vitro models using monolayer formed by epithelial cells from the human colon (Caco-2 cell) have been extensively used for evaluating the permeability, bioavailability, intestinal transport, and metabolism of toxic and biologically active compounds. Here, the strengths and limitations of both in vivo and in vitro techniques used to determine bioavailability are reviewed, along with current detailed data about biotransformation of mycotoxins. Furthermore, the molecular mechanism of mycotoxin effects is also discussed regarding the disorder of intestinal barrier integrity induced by mycotoxins.
Identifiants
pubmed: 33008111
pii: toxins12100628
doi: 10.3390/toxins12100628
pmc: PMC7601793
pii:
doi:
Substances chimiques
Mycotoxins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy
ID : INTER-COST LTC20015
Pays : International
Organisme : Czech National Program of Sustainability
ID : NPU I (LO1601, MSMT-43760/2015)
Pays : International
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