Long term alterations of growth after antenatal steroids in preterm twin pregnancies.
Anthropometry
Betamethasone
/ administration & dosage
Child Development
/ drug effects
Child, Preschool
Female
Glucocorticoids
/ administration & dosage
Humans
Infant
Infant, Newborn
Male
Pregnancy
Pregnancy, Twin
Prenatal Exposure Delayed Effects
Retrospective Studies
Sex Characteristics
Twins
/ statistics & numerical data
antenatal betamethasone
antenatal steroid (ANS)
dosage
early childhood
follow up
infancy
sex
twin pregnancy
Journal
Journal of perinatal medicine
ISSN: 1619-3997
Titre abrégé: J Perinat Med
Pays: Germany
ID NLM: 0361031
Informations de publication
Date de publication:
23 Feb 2021
23 Feb 2021
Historique:
received:
11
05
2020
accepted:
11
09
2020
pubmed:
4
10
2020
medline:
29
10
2021
entrez:
3
10
2020
Statut:
epublish
Résumé
To compare the long-term effects of antenatal betamethasone (ANS, ≤16 mg, =24 mg and >24 mg) in twins on infant and childhood growth. A retrospective cohort follow up study among 198 twins after ANS including three time points: U1 first neonatal examination after birth and in the neonatal period; U7 examination from the 21st to the 24th month of life and U9 examination from the 60th to the 64th month of life using data from copies of the children's examination booklets. Inclusion criteria are twin pregnancies with preterm labor, cervical shortening, preterm premature rupture of membranes, or vaginal bleeding, and exposure to ANS between 23+5 and 33+6 weeks. Outcome measures are dosage-dependent and sex-specific effects of ANS on growth (body weight, body length, head circumference, body mass index and ponderal index) up to 5.3 years. Overall, 99 live-born twin pairs were included. Negative effects of ANS on fetal growth persisted beyond birth, altered infant and childhood growth, independent of possible confounding factors. Overall weight percentile significantly decreased between infancy and early childhood by 18.8%. Birth weight percentiles significantly changed in a dose dependent and sex specific manner, most obviously in female-female and mixed pairs. The ponderal index significantly decreased up to 42.9%, BMI index increased by up to 33.8%. ANS results in long-term alterations in infant and childhood growth. Changes between infancy and early childhood in ponderal mass index and BMI, independent of dose or twin pair structure, might indicate an ANS associated increased risk for later life disease. First-time report on long-term ANS administration growth effects in twin pregnancies, showing persisting alterations beyond birth in infant and childhood growth up to 5.3 years as potential indicator of later life disease risk.
Identifiants
pubmed: 33010142
doi: 10.1515/jpm-2020-0204
pii: jpm-2020-0204
doi:
Substances chimiques
Glucocorticoids
0
Betamethasone
9842X06Q6M
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-137Informations de copyright
© 2020 Thorsten Braun et al., published by De Gruyter, Berlin/Boston.
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