Reconciling markedly discordant values of serum ferritin versus reticulocyte hemoglobin content.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
20
04
2020
accepted:
24
09
2020
revised:
02
09
2020
pubmed:
6
10
2020
medline:
1
9
2021
entrez:
5
10
2020
Statut:
ppublish
Résumé
To determine why serum ferritin and reticulocyte hemoglobin (RET-He), drawn to assess neonatal iron sufficiency, sometimes have markedly discordant results. Retrospective records review of five NICUs over 28 months, identifying all patients with a ferritin and RET-He within 48 h. We examined records of all who had marked discordance (one value >95th % reference interval, the other <5th %). Of 190 paired ferritin and RET-He measurements, 16 (8%) were markedly discordant. Fifteen of the 16 discordant samples involved a high ferritin and a low RET-He. In these, low MCV and high %Micro-R, and low MCH and high %HYPO-He were present. In total, 8 of the 15 had laboratory or clinical evidence of an inflammatory process and five had suspicion of infection documented. When ferritin and RET-He were discordant, erythrocyte microcytosis and hypochromasia suggested that the RET-He gave the more accurate interpretation; that iron deficiency was likely present.
Identifiants
pubmed: 33012780
doi: 10.1038/s41372-020-00845-2
pii: 10.1038/s41372-020-00845-2
doi:
Substances chimiques
Hemoglobins
0
Ferritins
9007-73-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
619-626Subventions
Organisme : NIDDK NIH HHS
ID : U54 DK110858
Pays : United States
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