Nociceptive signaling of P2X receptors in chronic pain states.
Microglia
Neuropathic pain
P2X2/3
P2X3
P2X4
Primary sensory neurons
Journal
Purinergic signalling
ISSN: 1573-9546
Titre abrégé: Purinergic Signal
Pays: Netherlands
ID NLM: 101250499
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
03
09
2020
accepted:
27
09
2020
pubmed:
6
10
2020
medline:
15
12
2021
entrez:
5
10
2020
Statut:
ppublish
Résumé
P2X3 monomeric receptors (P2X3Rs) and P2X2/3 heteromeric receptors (P2X2/3Rs) in primary sensory neurons and microglial P2X4 monomeric receptors (P2X4Rs) in the spinal dorsal horn (SDH) play important roles in neuropathic pain. In particular, P2X4R in the spinal microglia during peripheral nerve injury (PNI), experimental autoimmune neuritis, and herpes models are useful to explore the potential strategies for developing new drugs to treat neuropathic pain. Recently, novel P2X4 antagonists, NP-1815-PX and NC-2600, were developed, which demonstrated potent and specific inhibition against rodent and human P2X4Rs. The phase I study of NC-2600 has been completed, and no serious side effects were reported. The roles played by purinergic receptors in evoking neuropathic pain provide crucial insights into the pathogenesis of neuropathic pain.
Identifiants
pubmed: 33015745
doi: 10.1007/s11302-020-09743-w
pii: 10.1007/s11302-020-09743-w
pmc: PMC7955020
doi:
Substances chimiques
Purinergic P2X Receptor Antagonists
0
Receptors, Purinergic P2X
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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