Vaginal Er:YAG laser application in the menopausal ewe model: a randomised estrogen and sham-controlled trial.
Animals
Atrophy
/ diagnosis
Biopsy
/ methods
Disease Models, Animal
Estrogen Replacement Therapy
/ methods
Estrogens
/ pharmacology
Female
Lasers, Solid-State
/ therapeutic use
Low-Level Light Therapy
/ adverse effects
Menopause
Sheep
Treatment Outcome
Vagina
/ pathology
Vaginal Diseases
/ drug therapy
Atrophy
epithelium
estrogen
laser
planar biaxial testing
sheep
vagina
Journal
BJOG : an international journal of obstetrics and gynaecology
ISSN: 1471-0528
Titre abrégé: BJOG
Pays: England
ID NLM: 100935741
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
accepted:
25
09
2020
pubmed:
6
10
2020
medline:
18
5
2021
entrez:
5
10
2020
Statut:
ppublish
Résumé
To describe effects of non-ablative erbium-doped:yttrium-aluminium-garnet (Er:YAG) laser on vaginal atrophy induced by iatrogenic menopause in the ewe. Animal experimental, randomised, sham and estrogen-treatment controlled study with blinding for primary outcome. KU Leuven, Belgium. Twenty-four ewes. Menopause was surgically induced, after which the ewes were randomised to three groups receiving vaginal Er:YAG laser application three times, with a 1-month interval; three sham manipulations with a 1-month interval; or estrogen replacement and sham manipulations. At given intervals, ewes were clinically examined and vaginal wall biopsies were taken. Vaginal compliance was determined by passive biomechanical testing from explants taken at autopsy. Vaginal epithelial thickness (primary), composition of the lamina propria (collagen, elastin, glycogen and vessel content), vaginal compliance, clinical signs. Animals exposed to Er:YAG laser application and sham manipulation, but not to estrogens, displayed a significant and comparable increase in vaginal epithelial thickness between baseline and 7 days after the third application (69% and 67%, respectively, both P < 0.0008). In laser-treated ewes, temporary vaginal discharge and limited thermal injury were observed. Estrogen-substituted ewes displayed a more prominent increase in epithelial thickness (202%; P < 0.0001) and higher vaginal compliance (P < 0.05). None of the interventions induced changes in the lamina propria. Vaginal Er:YAG laser has comparable effect to sham manipulation in menopausal ewes. Vaginal Er:YAG laser has comparable effect to sham manipulation in menopausal ewes #LASER #GSM #RCT.
Identifiants
pubmed: 33017509
doi: 10.1111/1471-0528.16558
doi:
Substances chimiques
Estrogens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1087-1096Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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