Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.
AMP-Activated Protein Kinases
/ genetics
Acylation
Adult
Aged
Animals
Cell Line
Cohort Studies
Colchicine
/ pharmacology
Diabetes Mellitus
/ diagnostic imaging
Disease Models, Animal
Echocardiography
Gene Expression Regulation
Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
/ genetics
Hexosamines
/ metabolism
Humans
Hypertrophy, Right Ventricular
/ diagnostic imaging
Male
Metabolome
Middle Aged
Mitochondria
/ drug effects
Monocrotaline
/ administration & dosage
Myocytes, Cardiac
/ drug effects
Protein Processing, Post-Translational
Rats
Rats, Sprague-Dawley
Ventricular Dysfunction, Right
/ diagnostic imaging
metabolism
mitochondria
post-translational modification
pulmonary hypertension
right ventricle
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
01 Oct 2020
01 Oct 2020
Historique:
received:
17
09
2020
revised:
22
09
2020
accepted:
23
09
2020
entrez:
6
10
2020
pubmed:
7
10
2020
medline:
3
3
2021
Statut:
epublish
Résumé
The hexosamine biosynthetic pathway (HBP) converts glucose to uridine-diphosphate-
Identifiants
pubmed: 33019763
pii: ijms21197278
doi: 10.3390/ijms21197278
pmc: PMC7582480
pii:
doi:
Substances chimiques
Hexosamines
0
Monocrotaline
73077K8HYV
Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
EC 2.6.1.16
AMP-Activated Protein Kinases
EC 2.7.11.31
Colchicine
SML2Y3J35T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL140100
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL144472
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL140100
Pays : United States
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