Developmental influences on symptom expression in antipsychotic-naïve first-episode psychosis.
Adolescence
age effects
antipsychotic-naïve
psychotic symptoms
schizophrenia
Journal
Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
pubmed:
7
10
2020
medline:
16
7
2022
entrez:
6
10
2020
Statut:
ppublish
Résumé
The neurodevelopmental model of psychosis was established over 30 years ago; however, the developmental influence on psychotic symptom expression - how age affects clinical presentation in first-episode psychosis - has not been thoroughly investigated. Using generalized additive modeling, which allows for linear and non-linear functional forms of age-related change, we leveraged symptom data from a large sample of antipsychotic-naïve individuals with first-episode psychosis ( Perceptual positive symptom severity significantly decreased with increasing age ( These findings suggest that as maturation proceeds, perceptual symptoms attenuate while non-perceptual symptoms are enhanced. Findings underscore how pathological brain-behavior relationships vary as a function of development.
Sections du résumé
BACKGROUND
The neurodevelopmental model of psychosis was established over 30 years ago; however, the developmental influence on psychotic symptom expression - how age affects clinical presentation in first-episode psychosis - has not been thoroughly investigated.
METHODS
Using generalized additive modeling, which allows for linear and non-linear functional forms of age-related change, we leveraged symptom data from a large sample of antipsychotic-naïve individuals with first-episode psychosis (
RESULTS
Perceptual positive symptom severity significantly decreased with increasing age (
CONCLUSIONS
These findings suggest that as maturation proceeds, perceptual symptoms attenuate while non-perceptual symptoms are enhanced. Findings underscore how pathological brain-behavior relationships vary as a function of development.
Identifiants
pubmed: 33019960
doi: 10.1017/S0033291720003463
pii: S0033291720003463
pmc: PMC8021611
mid: NIHMS1668242
doi:
Substances chimiques
Antipsychotic Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1698-1709Subventions
Organisme : NCRR NIH HHS
ID : UL1 RR024153
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001857
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000056
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108568
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH112774
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH094328
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH084053
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH103204
Pays : United States
Références
Acta Psychiatr Scand. 2009 Jun;119(6):494-500
pubmed: 19207132
Psychol Med. 2001 Feb;31(2):189-95
pubmed: 11232907
Br J Psychiatry. 1993 Jan;162:80-6
pubmed: 8425144
Schizophr Bull. 2003;29(4):671-92
pubmed: 14989406
Acta Psychiatr Scand. 1990 Jul;82(1):26-9
pubmed: 2399817
Arch Gen Psychiatry. 2003 Aug;60(8):837-44
pubmed: 12912767
Trends Cogn Sci. 2019 Feb;23(2):114-127
pubmed: 30583945
Eur Child Adolesc Psychiatry. 2017 Nov;26(11):1401-1405
pubmed: 28456857
Schizophr Res. 2013 Jun;147(1):125-131
pubmed: 23587696
Neuroimage. 2014 May 15;92:356-68
pubmed: 24384150
Nature. 2010 Nov 11;468(7321):187-93
pubmed: 21068826
World Psychiatry. 2015 Jun;14(2):189-97
pubmed: 26043337
Child Dev. 1987 Oct;58(5):1220-34
pubmed: 3665641
Rev Endocr Metab Disord. 2012 Sep;13(3):187-207
pubmed: 21603930
Schizophr Res. 2014 Dec;160(1-3):110-7
pubmed: 25458860
Clin Psychol Rev. 2017 Dec;58:59-75
pubmed: 29042139
Early Interv Psychiatry. 2017 Dec;11(6):453-460
pubmed: 28449199
Eur Psychiatry. 2007 Sep;22(6):371-9
pubmed: 17521890
Acta Psychiatr Scand. 2006 Nov;114(5):337-45
pubmed: 17022793
Curr Psychiatry Rep. 2006 Jun;8(3):179-83
pubmed: 19817067
J Am Acad Child Adolesc Psychiatry. 1992 Sep;31(5):968-76
pubmed: 1400132
J Am Acad Child Adolesc Psychiatry. 2011 Jul;50(7):681-686.e3
pubmed: 21703495
Am J Psychiatry. 2005 Oct;162(10):1966-9
pubmed: 16199847
Br J Psychiatry. 2012 Jul;201(1):26-32
pubmed: 22500011
Cereb Cortex. 2013 May;23(5):1108-17
pubmed: 22535908
Am Psychol. 1993 Feb;48(2):90-101
pubmed: 8442578
Schizophr Res. 2019 Nov;213:15-22
pubmed: 31345704
Schizophr Res. 2009 May;110(1-3):165-72
pubmed: 19230622
Eur Arch Psychiatry Clin Neurosci. 1992;242(2-3):109-18
pubmed: 1486099
Eur Psychiatry. 2017 Feb;40:65-75
pubmed: 27992836
Psychol Methods. 2012 Jun;17(2):228-43
pubmed: 22309957
Ann Acad Med Singap. 2009 May;38(5):383-5
pubmed: 19521636
Acta Psychiatr Scand Suppl. 2005;(427):35-42
pubmed: 15877720
Schizophr Bull. 2004;30(4):813-25
pubmed: 15957198
Schizophr Res. 1999 May 4;37(1):91-5
pubmed: 10227111
Psychol Med. 2012 Sep;42(9):1857-63
pubmed: 22225730
Dev Psychopathol. 2009 Winter;21(1):47-68
pubmed: 19144222
Am J Psychiatry. 2003 Jan;160(1):13-23
pubmed: 12505794
Dev Psychopathol. 2016 May;28(2):527-36
pubmed: 26856897
Psychol Med. 2013 Feb;43(2):259-68
pubmed: 22651857
Schizophr Res. 2009 Sep;113(2-3):189-99
pubmed: 19628375
J Nerv Ment Dis. 2007 Dec;195(12):968-75
pubmed: 18091189
Br J Psychiatry. 2015 Sep;207(3):198-206
pubmed: 26329563
Psychol Med. 2006 May;36(5):649-58
pubmed: 16515734
J Am Acad Child Adolesc Psychiatry. 2008 May;47(5):556-564
pubmed: 18356762
Psychol Med. 2007 Jul;37(7):927-34
pubmed: 17288638
Psychol Bull. 1987 May;101(3):393-403
pubmed: 3602247
Prog Neurobiol. 2010 Nov;92(3):345-69
pubmed: 20558235
Mol Psychiatry. 2012 Dec;17(12):1228-38
pubmed: 22488257
Dev Psychol. 2001 May;37(3):404-17
pubmed: 11370915
Schizophr Res. 2002 Mar 1;54(1-2):17-23
pubmed: 11853974
Early Interv Psychiatry. 2019 Aug;13(4):745-751
pubmed: 29602244
Br J Psychiatry. 2011 Mar;198(3):173-5
pubmed: 21357874
Mol Psychiatry. 2020 Aug;25(8):1631-1639
pubmed: 31959848
Annu Rev Clin Psychol. 2008;4:189-216
pubmed: 18370616
Neurosci Biobehav Rev. 2018 Nov;94:179-195
pubmed: 30201220
Schizophr Bull. 1992;18(3):373-86
pubmed: 1411328
Psychiatry Res. 2005 Jan 30;133(1):35-43
pubmed: 15698675
Arch Gen Psychiatry. 2006 Mar;63(3):250-8
pubmed: 16520429
Am J Psychiatry. 1998 Sep;155(9):1196-201
pubmed: 9734542
Schizophr Res. 2016 Jul;174(1-3):183-188
pubmed: 27102425
Psychiatry Res. 2011 Jun 30;188(1):13-7
pubmed: 21215461
BMC Psychiatry. 2012 Sep 19;12:150
pubmed: 22992395
Dev Cogn Neurosci. 2018 Apr;30:41-50
pubmed: 29275097
Neuroimage. 2019 Apr 15;190:144-153
pubmed: 29175199
Br J Psychiatry. 2006 Aug;189:137-43
pubmed: 16880483
Compr Psychiatry. 2009 Jan-Feb;50(1):13-9
pubmed: 19059508
Nord J Psychiatry. 2020 Oct;74(7):497-504
pubmed: 32242498
Cereb Cortex. 2020 Mar 14;30(3):1548-1558
pubmed: 31670797
Biol Psychiatry. 2017 Oct 1;82(7):511-521
pubmed: 28274468
Psychiatry Res. 2017 Sep;255:94-100
pubmed: 28531822
J Am Acad Child Adolesc Psychiatry. 2005 Aug;44(8):782-9
pubmed: 16034280
World Psychiatry. 2018 Feb;17(1):49-66
pubmed: 29352556
Br Med J (Clin Res Ed). 1987 Sep 19;295(6600):681-2
pubmed: 3117295
Arch Gen Psychiatry. 1986 Feb;43(2):114-24
pubmed: 3947207
Schizophr Res. 2008 Dec;106(2-3):286-93
pubmed: 18809298
J Child Psychol Psychiatry. 2009 Oct;50(10):1209-17
pubmed: 19490305
Psychiatry Res. 2013 Apr 30;206(2-3):151-7
pubmed: 23218915
J Consult Clin Psychol. 2002 Feb;70(1):79-95
pubmed: 11860059
J Individ Psychol. 1974 May;30(1):98-113
pubmed: 4857199
Am J Psychiatry. 2005 Mar;162(3):495-506
pubmed: 15741466
Nord J Psychiatry. 2008;62(5):334-41
pubmed: 18752104
Biol Psychiatry. 2006 Sep 1;60(5):463-71
pubmed: 16566898
Psychol Med. 2011 Feb;41(2):333-43
pubmed: 20459882