A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York City.
Adult
Age Factors
Aged
Brain Diseases
/ epidemiology
COVID-19
/ complications
Female
Hospital Mortality
Hospitalization
/ statistics & numerical data
Humans
Intubation, Intratracheal
/ statistics & numerical data
Male
Middle Aged
Nervous System Diseases
/ epidemiology
Neurotoxicity Syndromes
New York City
/ epidemiology
Organ Dysfunction Scores
Patient Discharge
/ statistics & numerical data
Prospective Studies
Sex Factors
Spinal Cord Diseases
/ epidemiology
Young Adult
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
26 01 2021
26 01 2021
Historique:
received:
14
07
2020
accepted:
14
09
2020
pubmed:
7
10
2020
medline:
2
2
2021
entrez:
6
10
2020
Statut:
ppublish
Résumé
To determine the prevalence and associated mortality of well-defined neurologic diagnoses among patients with coronavirus disease 2019 (COVID-19), we prospectively followed hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients and recorded new neurologic disorders and hospital outcomes. We conducted a prospective, multicenter, observational study of consecutive hospitalized adults in the New York City metropolitan area with laboratory-confirmed SARS-CoV-2 infection. The prevalence of new neurologic disorders (as diagnosed by a neurologist) was recorded and in-hospital mortality and discharge disposition were compared between patients with COVID-19 with and without neurologic disorders. Of 4,491 patients with COVID-19 hospitalized during the study timeframe, 606 (13.5%) developed a new neurologic disorder in a median of 2 days from COVID-19 symptom onset. The most common diagnoses were toxic/metabolic encephalopathy (6.8%), seizure (1.6%), stroke (1.9%), and hypoxic/ischemic injury (1.4%). No patient had meningitis/encephalitis or myelopathy/myelitis referable to SARS-CoV-2 infection and 18/18 CSF specimens were reverse transcriptase PCR negative for SARS-CoV-2. Patients with neurologic disorders were more often older, male, white, hypertensive, diabetic, intubated, and had higher sequential organ failure assessment (SOFA) scores (all Neurologic disorders were detected in 13.5% of patients with COVID-19 and were associated with increased risk of in-hospital mortality and decreased likelihood of discharge home. Many observed neurologic disorders may be sequelae of severe systemic illness.
Identifiants
pubmed: 33020166
pii: WNL.0000000000010979
doi: 10.1212/WNL.0000000000010979
pmc: PMC7905791
doi:
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e575-e586Subventions
Organisme : NIA NIH HHS
ID : P30 AG066512
Pays : United States
Organisme : NINDS NIH HHS
ID : 3U24NS11384401S1
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 American Academy of Neurology.
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