T Cell Receptor Is Required for Differentiation, but Not Maintenance, of Intestinal CD4

Animals CD4-Positive T-Lymphocytes / immunology Cell Differentiation / genetics Clonal Evolution / genetics Histocompatibility Antigens Class II / genetics Immunophenotyping Intestinal Mucosa / immunology Intraepithelial Lymphocytes / immunology Mice Receptors, Antigen, T-Cell / metabolism Receptors, Antigen, T-Cell, alpha-beta / metabolism Signal Transduction Single-Cell Analysis T-Lymphocyte Subsets / immunology
T cell receptor TCR repertoire cell plasticity intestinal epithelium intestinal intraepithelial lymphocytes single-cell gene expression tissue adaptation

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
17 11 2020
Historique:
received: 18 11 2019
revised: 02 07 2020
accepted: 09 09 2020
pubmed: 7 10 2020
medline: 1 5 2021
entrez: 6 10 2020
Statut: ppublish

Résumé

The gut epithelium is populated by intraepithelial lymphocytes (IELs), a heterogeneous T cell population with cytotoxic and regulatory properties, which can be acquired at the epithelial layer. However, the role of T cell receptor (TCR) in this process remains unclear. Single-cell transcriptomic analyses revealed distinct clonal expansions between cell states, with CD4

Identifiants

DOI: 10.1016/j.immuni.2020.09.003 PMID: 33022229 PMC: PMC7677182
pubmed: 33022229
pii: S1074-7613(20)30397-6
doi: 10.1016/j.immuni.2020.09.003
pmc: PMC7677182
mid: NIHMS1630465
pii:
doi:

Substances chimiques

Histocompatibility Antigens Class II 0
Receptors, Antigen, T-Cell 0
Receptors, Antigen, T-Cell, alpha-beta 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1001-1014.e20

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK093674
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113375
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI144827
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Angelina M Bilate (AM)

Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA. Electronic address: abilate@rockefeller.edu.

Mariya London (M)

Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.

Tiago B R Castro (TBR)

Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY 10065, USA.

Luka Mesin (L)

Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY 10065, USA.

Juliana Bortolatto (J)

Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY 10065, USA.

Suppawat Kongthong (S)

Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.

Audrey Harnagel (A)

Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.

Gabriel D Victora (GD)

Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY 10065, USA.

Daniel Mucida (D)

Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA. Electronic address: mucida@rockefeller.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › T Cell Receptor Is Required for...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › T Cell Receptor Is Required for...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › T Cell Receptor Is Required for...
questionsmedicales.fr › Phénomènes génétiques › Évolution clonale › T Cell Receptor Is Required for...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes d'histocompatibilité de classe II › T Cell Receptor Is Required for...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Immunophénotypage › T Cell Receptor Is Required for...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › T Cell Receptor Is Required for...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes intra-épithéliaux › T Cell Receptor Is Required for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › T Cell Receptor Is Required for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › T Cell Receptor Is Required for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Récepteur lymphocytaire T antigène, alpha-bêta › T Cell Receptor Is Required for...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › T Cell Receptor Is Required for...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › T Cell Receptor Is Required for...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › T Cell Receptor Is Required for...