A Prospective Study of Diffusion-weighted Magnetic Resonance Imaging as an Early Prognostic Biomarker in Chemoradiotherapy in Squamous Cell Carcinomas of the Anus.
Aged
Anus Neoplasms
/ diagnostic imaging
Biomarkers, Tumor
/ analysis
Carcinoma, Squamous Cell
/ diagnostic imaging
Chemoradiotherapy
/ methods
Diffusion Magnetic Resonance Imaging
/ methods
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
/ diagnostic imaging
Prognosis
Prospective Studies
Tumor Burden
ADC mean
anal cancer
diffusion-weighted MRI
functional imaging
prognostic biomarkers
Journal
Clinical oncology (Royal College of Radiologists (Great Britain))
ISSN: 1433-2981
Titre abrégé: Clin Oncol (R Coll Radiol)
Pays: England
ID NLM: 9002902
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
13
03
2020
revised:
15
07
2020
accepted:
03
09
2020
pubmed:
8
10
2020
medline:
25
5
2021
entrez:
7
10
2020
Statut:
ppublish
Résumé
The use of diffusion-weighted magnetic resonance imaging (DW-MRI) as a prognostic marker of treatment response would enable early individualisation of treatment. We aimed to quantify the changes in mean apparent diffusion coefficient (ΔADC This prospective study recruited patients with localised anal cancer between October 2014 and November 2017. DW-MRI was carried out at diagnosis and after fraction 8-10 of radical CRT. A region of interest was delineated for all primary tumours and any lymph nodes >2 cm on high-resolution T Twenty-three of 29 recruited patients underwent paired DW-MRI scans. Twenty-six regions of interest were delineated among the 23 evaluable patients. The median (range) tumour volume was 13.6 cm We demonstrated a potential correlation between patients with ΔADC
Identifiants
pubmed: 33023818
pii: S0936-6555(20)30364-2
doi: 10.1016/j.clon.2020.09.003
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
874-883Subventions
Organisme : Medical Research Council
ID : MC_PC_12001/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00001/2
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5529/A16895
Pays : United Kingdom
Informations de copyright
Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.