Mucous membrane grafting (fibrin glue vs. suture) for lid margin pathologies in Stevens-Johnson syndrome: randomized comparative study.
Journal
Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
04
06
2020
accepted:
21
09
2020
revised:
23
08
2020
pubmed:
8
10
2020
medline:
10
7
2021
entrez:
7
10
2020
Statut:
ppublish
Résumé
To compare fibrin glue (with three cardinal sutures) (FG) and polygalactin suture (PS) for mucous membrane grafting (MMG) in terms of graft apposition and recurrence of lid margin keratinization (LMK) and metaplastic lashes (ML) in patients with Stevens-Johnson syndrome (SJS). Prospective randomized comparative interventional study. Twenty patients diagnosed with SJS and lid margin abnormalities including LMK with or without ML were randomized to undergo either fibrin glue (FG)-assisted MMG (n = 10) or continuous 8-0 polygalactin suture (PS)-assisted MMG (n = 10). They were evaluated preoperatively and during follow-up at 1 week and 1, 2, 3, and 6 months. The parameters assessed were best-corrected visual acuity (BCVA), tear break-up time (TBUT), Schirmer-1 test, corneal and conjunctival complications, graft apposition and width (GW), LMK, ML, impression cytology, and operative time. The primary outcome measures are incidence of graft displacement and recurrence of LMK and ML. None of the eyelids in FG group (0/40) and 1 eyelid in PS group (1/40) had graft displacement. Recurrence of LMK occurred in 7.5% of eyelids (3/40) in both the study groups. Recurrence of ML occurred in 2.5% (1/40) in FG group and 5% (2/40) in PS group. The mean operative time for MMG in FG group was 39.5 ± 2.40 min and in PS group was 56 ± 1.63 min (p = 0.001). As graft apposition with suture involves significantly longer intraoperative time, if cost is not a limiting factor then fibrin glue is a viable option for the MMG for lid margin pathologies.
Identifiants
pubmed: 33024323
doi: 10.1038/s41433-020-01203-4
pii: 10.1038/s41433-020-01203-4
pmc: PMC8225623
doi:
Substances chimiques
Fibrin Tissue Adhesive
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
1985-1992Références
Dipascuale M, Espana E, Liu D, Kawakita T, Li W, Gao Y, et al. Correlation of corneal complications with eyelid cicatricial pathologies in patients with Stevens–Johnson syndrome and toxic epidermal necrolysis syndrome. Ophthalmology. 2005;112:904–12.
doi: 10.1016/j.ophtha.2004.11.035
Pullum K, Buckley R. Therapeutic and ocular surface indications for scleral contact lenses. Ocul Surf. 2007;5:40–8.
doi: 10.1016/S1542-0124(12)70051-4
Iyer G, Pillai VS, Srinivasan B, Guruswami S, Padmanabhan P. Mucous membrane grafting for lid margin keratinization in Stevens–Johnson syndrome: results. Cornea. 2010;29:146–51.
doi: 10.1097/ICO.0b013e3181ae2691
Fu Y, Liu J, Tseng SCG. Oral mucosal graft to correct lid margin pathologic features in cicatricial ocular surface diseases. Am J Ophthalmol. 2011;152:600–608.e1.
doi: 10.1016/j.ajo.2011.03.011
Koranyi G, Seregard S, Kopp ED. Cut and paste: a no suture, small incision approach to pterygium surgery. Br J Ophthalmol. 2004;88:911–4.
doi: 10.1136/bjo.2003.032854
Sharma N, Thenarasun SA, Kaur M, Pushker N, Khanna N, Agarwal T, et al. Adjuvant role of amniotic membrane transplantation in acute ocular stevens-johnson syndrome: a randomized control trial. Ophthalmology. 2016;123:484–91.
doi: 10.1016/j.ophtha.2015.10.027
Queiroz de Paiva AR, Abreu de Azevedo Fraga L, Torres VLL. Surgical reconstruction of ocular surface tumors using fibrin sealant tissue adhesive. Ocul Oncol Pathol. 2016;2:207–11.
doi: 10.1159/000444532
Bahar I, Weinberger D, Dan G, Avisar R. Pterygium surgery: fibrin glue versus vicryl sutures for conjunctival closure. Cornea. 2006;25:1168–72.
doi: 10.1097/01.ico.0000240087.32922.ee
Hall RC, Logan AJ, Wells AP. Comparison of fibrin glue with sutures for pterygium excision surgery with conjunctival autografts. Clin Exp Ophthalmol. 2009;37:584–9.
doi: 10.1111/j.1442-9071.2009.02105.x
Ratnalingam V, Keat Eu AL, Ng GL, Taharin R, John E. Fibrin adhesive is better than sutures in pterygium surgery. Cornea. 2010;29:485–9.
doi: 10.1097/ICO.0b013e3181c29696
Sotozono C, Ang LPK, Koizumi N, Higashihara H, Ueta M, Inatomi T, et al. New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome. Ophthalmology. 2007;114:1294–302.
doi: 10.1016/j.ophtha.2006.10.029
Kompella VB, Sangwan VS, Bansal AK, Garg P, Aasuri MK, Rao GN. Ophthalmic complications and management of Stevens-Johnson syndrome at a tertiary eye care centre in south India. Indian J Ophthalmol. 2002;50:283–6.
pubmed: 12532492
Weinberg DA, Tham V, Hardin N, Antley C, Cohen AJ, Hunt K, et al. Eyelid mucous membrane grafts: a histologic study of hard palate, nasal turbinate, and buccal mucosal grafts. Ophthal Plast Reconstr Surg. 2007;23:211–6.
doi: 10.1097/IOP.0b013e318050d2d1
Henderson HWA, Collin JRO. Mucous membrane grafting. In: Geerling G, Brewitt H, editors. Developments in ophthalmology. Basel: Karger; 2008. p. 230–42.
Araújo ALde, Ricardo JRdaS, Sakai VN, Barros JNde, Gomes JÁP. Impression cytology and in vivo confocal microscopy in corneas with total limbal stem cell deficiency. Arq Bras Oftalmol. 2013;76:305–8.
doi: 10.1590/S0004-27492013000500011
Fatima A, Iftekhar G, Sangwan VS, Vemuganti GK. Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium. Eye. 2008;22:1161–7.
doi: 10.1038/sj.eye.6702895