In vivo absolute quantification of hepatic γ-ATP concentration in mice using

Adenosine Triphosphate / analysis Adipose Tissue / metabolism Animals Disease Models, Animal Female Insulin Resistance Lipodystrophy / metabolism Liver / chemistry Male Mice Mice, Inbred C57BL Mice, Inbred NOD Non-alcoholic Fatty Liver Disease / metabolism Nuclear Magnetic Resonance, Biomolecular / instrumentation Phosphorus / analysis Recombinant Proteins / biosynthesis Reproducibility of Results Sterol Regulatory Element Binding Protein 1 / biosynthesis
diabetes hepatobiliary system mitochondrial function mouse obesity phosphorus MRS/MRSI spectroscopic quantification

Journal

NMR in biomedicine
ISSN: 1099-1492
Titre abrégé: NMR Biomed
Pays: England
ID NLM: 8915233

Informations de publication

Date de publication:
02 2021
Historique:
received: 03 04 2020
revised: 14 09 2020
accepted: 15 09 2020
pubmed: 8 10 2020
medline: 19 11 2021
entrez: 7 10 2020
Statut: ppublish

Résumé

Measurement of ATP concentrations and synthesis in humans indicated abnormal hepatic energy metabolism in obesity, non-alcoholic fatty liver disease (NAFLD) and Type 2 diabetes. Further mechanistic studies on energy metabolism require the detailed phenotyping of specific mouse models. Thus, this study aimed to establish and evaluate a robust and fast single voxel

Identifiants

DOI: 10.1002/nbm.4422 PMID: 33025629
pubmed: 33025629
doi: 10.1002/nbm.4422
doi:

Substances chimiques

Recombinant Proteins 0
Sterol Regulatory Element Binding Protein 1 0
Phosphorus 27YLU75U4W
Adenosine Triphosphate 8L70Q75FXE

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e4422

Informations de copyright

© 2020 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.

Références

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Auteurs

Maik Rothe (M)

Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Düsseldorf, Germany.
German Center for Diabetes Research, München-Neuherberg, Germany.

Corinna Wessel (C)

Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Düsseldorf, Germany.
German Center for Diabetes Research, München-Neuherberg, Germany.

Sandra Cames (S)

Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Düsseldorf, Germany.
German Center for Diabetes Research, München-Neuherberg, Germany.

Julia Szendroedi (J)

Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Düsseldorf, Germany.
German Center for Diabetes Research, München-Neuherberg, Germany.
Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Volker Burkart (V)

Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Düsseldorf, Germany.
German Center for Diabetes Research, München-Neuherberg, Germany.

Jong-Hee Hwang (JH)

Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Düsseldorf, Germany.
German Center for Diabetes Research, München-Neuherberg, Germany.
ORCID: 0000-0003-2716-4112

Michael Roden (M)

Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Düsseldorf, Germany.
German Center for Diabetes Research, München-Neuherberg, Germany.
Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › In vivo absolute quantification of hepatic...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › In vivo absolute quantification of hepatic...
questionsmedicales.fr › Eucaryotes › Animaux › In vivo absolute quantification of hepatic...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › In vivo absolute quantification of hepatic...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › In vivo absolute quantification of hepatic...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Dermatoses métaboliques › Lipodystrophie › In vivo absolute quantification of hepatic...
questionsmedicales.fr › Système digestif › Foie › In vivo absolute quantification of hepatic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › In vivo absolute quantification of hepatic...
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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › In vivo absolute quantification of hepatic...
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questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › In vivo absolute quantification of hepatic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › In vivo absolute quantification of hepatic...
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