Gout Flare Severity From the Patient Perspective: A Qualitative Interview Study.
Journal
Arthritis care & research
ISSN: 2151-4658
Titre abrégé: Arthritis Care Res (Hoboken)
Pays: United States
ID NLM: 101518086
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
15
09
2020
received:
30
06
2020
accepted:
29
09
2020
pubmed:
8
10
2020
medline:
15
2
2022
entrez:
7
10
2020
Statut:
ppublish
Résumé
The patient experience of a gout flare is multidimensional. To establish the most appropriate methods of flare measurement, there is a need to understand the complete experience of a flare. This qualitative study aimed to examine what factors contribute to the severity of a flare from the patient perspective. Face-to-face interviews were conducted with patients with gout. Participants were asked to share their experience with their worst gout flare and contrast it to their experience of a less severe or mild flare. Interviews were audio recorded and transcribed verbatim. Data were analyzed using a reflexive thematic approach. In total, 22 participants with gout (17 male participants, mean age 66.5 years) were interviewed at an academic center in Auckland, New Zealand. Four key themes were identified as contributing to the severity of a flare: 1) flare characteristics (pain intensity, joint swelling, redness and warmth, duration, and location); 2) impact on function (including walking, activities of daily living, wearing footwear, and sleep); 3) impact on family and social life (dependency on others, social connection, and work); and 4) psychological impact (depression, anxiety, irritability, and sense of control). A wide range of interconnecting factors contribute to the severity of a gout flare from the patient perspective. Capturing these domains in long-term gout studies would provide a more meaningful and accurate representation of cumulative flare burden.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
317-323Subventions
Organisme : Catalan Society of Rheumatology
Organisme : Spanish Foundation for Rheumatology
Organisme : Auckland Medical Research Foundation
Informations de copyright
© 2020, American College of Rheumatology.
Références
Tatlock S, Rudell K, Panter C, Arbuckle R, Harrold L, Taylor W, et al. What outcomes are important for gout patients? In-depth qualitative research into the gout patient experience to determine optimal endpoints for evaluating therapeutic interventions. Patient 2017;10:65-79.
Stewart S, Tallon A, Taylor W, Gaffo A, Dalbeth N. How flare prevention outcomes are reported in gout studies: a systematic review and content analysis of randomized controlled trials. Semin Arthrititis Rheum 2020;50:303-13.
Stamp L, Morrillon M, Taylor W, Dalbeth N, Singh J, Lassere M, et al. Variability in the reporting of serum urate and flares in gout clinical trials: need for minimum reporting requirements. J Rheumatol 2018;45:419-24.
Stewart S, Taylor W, Gaffo A, Slark A, Gott M, Dalbeth N. The experience of a gout flare: a meta-synthesis of qualitative studies. Semin Arthritis Rheum 2020;50:805-11.
Neogi T, Jansen TL, Dalbeth N, Fransen J, Schumacher HR, Berendsen D, et al. 2015 gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheumatol 2015;67:2557-68.
Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol 2006;3:77-101.
Schumacher H, Taylor W, Edwards L, Grainger R, Schlesinger N, Dalbeth N, et al. Outcome domains for studies of acute and chronic gout. J Rheumatol 2009;36:2342-5.
Gaffo AL, Dalbeth N, Saag KG, Singh JA, Rahn EJ, Mudano AS, et al. Validation of a definition of flare in patients with established gout. Arthritis Rheumatol 2018;70:462-7.
Khanna P, Nuki G, Bardin T, Tausche AK, Forsythe A, Goren A, et al. Tophi and frequent gout flares are associated with impairments to quality of life, productivity, and increased healthcare resource use: results from a cross-sectional survey. Health Qual Life Outcomes 2012:10:117-27.
Taylor W, Dalbeth N, Singh JA, Rahn EJ, Mudano AS, Chen Y, et al. Flare rate thresholds for patient assessment of gout disease activity states. J Rheumatol 2021;48:293-8.
Dalbeth N, Petrie KJ, House M, Chong J, Leung W, Chegudi R, et al. Illness perceptions in patients with gout and the relationship with progression of musculoskeletal disability. Arthritis Care Res (Hoboken) 2011;63:1605-12.
Chandratre P, Mallen C, Roddy E, Liddle J, Richardson J. “You want to get on with the rest of your life”: a qualitative study of health-related quality of life in gout. Clin Rheumatol 2016;35:1197-205.