Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
Case-Control Studies
DNA Methylation
Epigenesis, Genetic
Fibroblasts
/ metabolism
Friedreich Ataxia
/ genetics
Gene Silencing
Heterochromatin
Histone-Lysine N-Methyltransferase
/ antagonists & inhibitors
Humans
Iron-Binding Proteins
/ antagonists & inhibitors
Leukocytes, Mononuclear
/ metabolism
Frataxin
Friedreich's ataxia
drug screening
epigenetics
frataxin
histone methylation
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
25 12 2020
25 12 2020
Historique:
received:
28
08
2020
pubmed:
9
10
2020
medline:
26
3
2021
entrez:
8
10
2020
Statut:
ppublish
Résumé
The molecular mechanisms of reduced frataxin (
Identifiants
pubmed: 33028632
pii: S0021-9258(17)50675-4
doi: 10.1074/jbc.RA120.015533
pmc: PMC7939392
pii:
doi:
Substances chimiques
Heterochromatin
0
Iron-Binding Proteins
0
Histone-Lysine N-Methyltransferase
EC 2.1.1.43
KMT5C protein, human
EC 2.1.1.43
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17973-17985Subventions
Organisme : Wellcome Trust
ID : 106169/ZZ14/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203141/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Informations de copyright
© 2020 Vilema-Enríquez et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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