Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
07 10 2020
07 10 2020
Historique:
received:
30
05
2019
revised:
24
12
2019
accepted:
31
08
2020
entrez:
8
10
2020
pubmed:
9
10
2020
medline:
24
6
2021
Statut:
ppublish
Résumé
Pathological remodeling of the myocardium has long been known to involve oxidant signaling, but strategies using systemic antioxidants have generally failed to prevent it. We sought to identify key regulators of oxidant-mediated cardiac hypertrophy amenable to targeted pharmacological therapy. Specific isoforms of the aquaporin water channels have been implicated in oxidant sensing, but their role in heart muscle is unknown. RNA sequencing from human cardiac myocytes revealed that the archetypal
Identifiants
pubmed: 33028705
pii: 12/564/eaay2176
doi: 10.1126/scitranslmed.aay2176
pii:
doi:
Substances chimiques
Aquaporin 1
146410-94-8
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.