Patrick Gilon

Affiliations

Pole of Endocrinology, Diabetes and Nutrition (EDIN), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, Avenue Hippocrate 55, B1.55.06 B-1200 Brussels, Belgium.

Publications (16)

The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis.

Journal of cell science

Avec: Beichen Xie , Styliani Panagiotou , Jing Cen , Patrick Gilon , Peter Bergsten , Olof Idevall-Hagren

GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function.

Cell reports

Avec: Nour Zaïmia , Joelle Obeid , Annie Varrault , Julia Sabatier , Christophe Broca , Patrick Gilon , Safia Costes , Gyslaine Bertrand , Magalie A Ravier

Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped.

Diabetologia

Avec: Mohammad Tariq , Arnaldo H de Souza , Mohammed Bensellam , Heeyoung Chae , Manon Jaffredo , Anne-Françoise Close , Jean-Philippe Deglasse , Laila R B Santos , Antoine Buemi , Nizar I Mourad , Anne Wojtusciszyn , Matthieu Raoux , Patrick Gilon , Christophe Broca , Jean-Christophe Jonas

Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide.

Science translational medicine

Avec: Virginie Montiel , Ramona Bella , Lauriane Y M Michel , Hrag Esfahani , Delphine De Mulder , Emma L Robinson , Jean-Philippe Deglasse , Malte Tiburcy , Pak Hin Chow , Jean-Christophe Jonas , Patrick Gilon , Benjamin Steinhorn , Thomas Michel , Christophe Beauloye , Luc Bertrand , Charlotte Farah , Flavia Dei Zotti , Huguette Debaix , Caroline Bouzin , Davide Brusa , Sandrine Horman , Jean-Louis Vanoverschelde , Olaf Bergmann , Dimitri Gilis , Marianne Rooman , Alessandra Ghigo , Simonetta Geninatti-Crich , Andrea Yool , Wolfram H Zimmermann , H Llewelyn Roderick , Olivier Devuyst , Jean-Luc Balligand

The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes.

Journal of molecular biology

Avec: Patrick Gilon

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Molecular metabolism

Avec: Bilal Singh , Firas Khattab , Heeyoung Chae , Lieven Desmet , Pedro L Herrera , Patrick Gilon

Glucose inhibits glucagon secretion by decreasing [Ca

Molecular metabolism

Avec: Bilal Singh , Firas Khattab , Patrick Gilon

ER stress increases expression of intracellular calcium channel RyR1 to modify Ca

The Journal of biological chemistry

Avec: Irina X Zhang , Andrea Herrmann , Juan Leon , Sivakumar Jeyarajan , Anoop Arunagiri , Peter Arvan , Patrick Gilon , Leslie S Satin

3D evaluation of the extracellular matrix of hypoxic pancreatic islets using light sheet fluorescence microscopy.

Islets

Avec: Matias Ramirez , Estelle Bastien , Heeyoung Chae , Pierre Gianello , Patrick Gilon , Caroline Bouzin

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.

Diabetologia

Avec: Mohammed Bensellam , Yan-Chuan Shi , Jeng Yie Chan , D Ross Laybutt , Heeyoung Chae , Michel Abou-Samra , Evan G Pappas , Helen E Thomas , Patrick Gilon , Jean-Christophe Jonas

SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.

Molecular metabolism

Avec: Heeyoung Chae , Robert Augustin , Eva Gatineau , Eric Mayoux , Mohammed Bensellam , Nancy Antoine , Firas Khattab , Bao-Khanh Lai , Davide Brusa , Birgit Stierstorfer , Holger Klein , Bilal Singh , Lucie Ruiz , Michael Pieper , Michael Mark , Pedro L Herrera , Fiona M Gribble , Frank Reimann , Anne Wojtusciszyn , Christophe Broca , Nano Rita , Lorenzo Piemonti , Patrick Gilon

γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion.

The Journal of biological chemistry

Avec: Qian Yu , Bao Khanh Lai , Parvin Ahooghalandari , Anders Helander , Erik Gylfe , Patrick Gilon , Anders Tengholm

LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes.

Biochemical and biophysical research communications

Avec: Paulina Karen Mendoza Sanchez , Mona Khazaei , Eva Gatineau , Shirin Geravandi , Blaz Lupse , Huan Liu , Ralf Dringen , Anne Wojtusciszyn , Patrick Gilon , Kathrin Maedler , Amin Ardestani

Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion.

International journal of molecular sciences

Avec: Min Li , Ruifan Zhang , Qian Ge , Lingzhi Yue , Dan Ma , Firas Khattab , Wenhua Xie , Yewei Cui , Patrick Gilon , Xueya Zhao , Xi Li , Rui Cheng

GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models.

Diabetologia

Avec: Vyron Gorgogietas , Bahareh Rajaei , Chae Heeyoung , Bruno J Santacreu , Sandra Marín-Cañas , Paraskevi Salpea , Toshiaki Sawatani , Anyishai Musuaya , María N Arroyo , Cristina Moreno-Castro , Khadija Benabdallah , Celine Demarez , Sanna Toivonen , Cristina Cosentino , Nathalie Pachera , Maria Lytrivi , Ying Cai , Lode Carnel , Cris Brown , Fumihiko Urano , Piero Marchetti , Patrick Gilon , Decio L Eizirik , Miriam Cnop , Mariana Igoillo-Esteve

The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner.

The Journal of endocrinology

Avec: Nirun Hewawasam , Debalina Sakar , Olivia Bolton , Blerinda Delishaj , Maha Almutairi , Aileen King , Ayse S Dereli , Chloe Despontin , Patrick Gilon , Sue Reeves , Michael Patterson , Astrid Christine Hauge-Evans

Réseau de co-auteurs

Heeyoung Chae 5 collaborations

Firas Khattab 4 collaborations

Christophe Broca 3 collaborations

Mohammed Bensellam 3 collaborations

Anne Wojtusciszyn 3 collaborations

Jean-Christophe Jonas 3 collaborations

Bilal Singh 3 collaborations

Jean-Philippe Deglasse 2 collaborations

Caroline Bouzin 2 collaborations

Davide Brusa 2 collaborations

Pedro L Herrera 2 collaborations

Eva Gatineau 2 collaborations

Beichen Xie 1 collaboration

Styliani Panagiotou 1 collaboration

Jing Cen 1 collaboration

Peter Bergsten 1 collaboration

Olof Idevall-Hagren 1 collaboration

Nour Zaïmia 1 collaboration

Joelle Obeid 1 collaboration

Annie Varrault 1 collaboration

Julia Sabatier 1 collaboration

Safia Costes 1 collaboration

Gyslaine Bertrand 1 collaboration

Magalie A Ravier 1 collaboration

Mohammad Tariq 1 collaboration

Arnaldo H de Souza 1 collaboration

Manon Jaffredo 1 collaboration

Anne-Françoise Close 1 collaboration

Laila R B Santos 1 collaboration

Antoine Buemi 1 collaboration

Nizar I Mourad 1 collaboration

Matthieu Raoux 1 collaboration

Virginie Montiel 1 collaboration

Ramona Bella 1 collaboration

Lauriane Y M Michel 1 collaboration

Hrag Esfahani 1 collaboration

Delphine De Mulder 1 collaboration

Emma L Robinson 1 collaboration

Malte Tiburcy 1 collaboration

Pak Hin Chow 1 collaboration

Benjamin Steinhorn 1 collaboration

Thomas Michel 1 collaboration

Christophe Beauloye 1 collaboration

Luc Bertrand 1 collaboration

Charlotte Farah 1 collaboration

Flavia Dei Zotti 1 collaboration

Huguette Debaix 1 collaboration

Sandrine Horman 1 collaboration

Jean-Louis Vanoverschelde 1 collaboration

Olaf Bergmann 1 collaboration

Dimitri Gilis 1 collaboration

Marianne Rooman 1 collaboration

Alessandra Ghigo 1 collaboration

Simonetta Geninatti-Crich 1 collaboration

Andrea Yool 1 collaboration

Wolfram H Zimmermann 1 collaboration

H Llewelyn Roderick 1 collaboration

Olivier Devuyst 1 collaboration

Jean-Luc Balligand 1 collaboration

Lieven Desmet 1 collaboration

Irina X Zhang 1 collaboration

Andrea Herrmann 1 collaboration

Juan Leon 1 collaboration

Sivakumar Jeyarajan 1 collaboration

Anoop Arunagiri 1 collaboration

Peter Arvan 1 collaboration

Leslie S Satin 1 collaboration

Matias Ramirez 1 collaboration

Estelle Bastien 1 collaboration

Pierre Gianello 1 collaboration

Yan-Chuan Shi 1 collaboration

Jeng Yie Chan 1 collaboration

D Ross Laybutt 1 collaboration

Michel Abou-Samra 1 collaboration

Evan G Pappas 1 collaboration

Helen E Thomas 1 collaboration

Robert Augustin 1 collaboration

Eric Mayoux 1 collaboration

Nancy Antoine 1 collaboration

Bao-Khanh Lai 1 collaboration

Birgit Stierstorfer 1 collaboration

Holger Klein 1 collaboration

Lucie Ruiz 1 collaboration

Michael Pieper 1 collaboration

Michael Mark 1 collaboration

Fiona M Gribble 1 collaboration

Frank Reimann 1 collaboration

Nano Rita 1 collaboration

Lorenzo Piemonti 1 collaboration

Qian Yu 1 collaboration

Bao Khanh Lai 1 collaboration

Parvin Ahooghalandari 1 collaboration

Anders Helander 1 collaboration

Erik Gylfe 1 collaboration

Anders Tengholm 1 collaboration

Paulina Karen Mendoza Sanchez 1 collaboration

Mona Khazaei 1 collaboration

Shirin Geravandi 1 collaboration

Blaz Lupse 1 collaboration

Huan Liu 1 collaboration

Ralf Dringen 1 collaboration

Kathrin Maedler 1 collaboration

Amin Ardestani 1 collaboration

Min Li 1 collaboration

Ruifan Zhang 1 collaboration

Qian Ge 1 collaboration

Lingzhi Yue 1 collaboration

Dan Ma 1 collaboration

Wenhua Xie 1 collaboration

Yewei Cui 1 collaboration

Xueya Zhao 1 collaboration

Xi Li 1 collaboration

Rui Cheng 1 collaboration

Vyron Gorgogietas 1 collaboration

Bahareh Rajaei 1 collaboration

Chae Heeyoung 1 collaboration

Bruno J Santacreu 1 collaboration

Sandra Marín-Cañas 1 collaboration

Paraskevi Salpea 1 collaboration

Toshiaki Sawatani 1 collaboration

Anyishai Musuaya 1 collaboration

María N Arroyo 1 collaboration

Cristina Moreno-Castro 1 collaboration

Khadija Benabdallah 1 collaboration

Celine Demarez 1 collaboration

Sanna Toivonen 1 collaboration

Cristina Cosentino 1 collaboration

Nathalie Pachera 1 collaboration

Maria Lytrivi 1 collaboration

Ying Cai 1 collaboration

Lode Carnel 1 collaboration

Cris Brown 1 collaboration

Fumihiko Urano 1 collaboration

Piero Marchetti 1 collaboration

Decio L Eizirik 1 collaboration

Miriam Cnop 1 collaboration

Mariana Igoillo-Esteve 1 collaboration

Nirun Hewawasam 1 collaboration

Debalina Sakar 1 collaboration

Olivia Bolton 1 collaboration

Blerinda Delishaj 1 collaboration

Maha Almutairi 1 collaboration

Aileen King 1 collaboration

Ayse S Dereli 1 collaboration

Chloe Despontin 1 collaboration

Sue Reeves 1 collaboration

Michael Patterson 1 collaboration

Astrid Christine Hauge-Evans 1 collaboration