D Ross Laybutt

Affiliations

Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
St Vincent's Clinical School, UNSW Sydney, Sydney, NSW 2010, Australia.

Publications (20)

Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and Above Metal Homeostasis and Antioxidant Response.

Biology

Avec: Mohammed Bensellam , D Ross Laybutt , Jean-Christophe Jonas

β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes.

Cell reports

Avec: Amit Lalwani , Joanna Warren , David Liuwantara , Wayne J Hawthorne , Philip J O'Connell , Frank J Gonzalez , Rebecca A Stokes , Jennifer Chen , D Ross Laybutt , Maria E Craig , Michael M Swarbrick , Cecile King , Jenny E Gunton

Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity.

Nature communications

Avec: Chenxu Yan , Tianshu Zeng , Kailun Lee , Max Nobis , Kim Loh , Luoning Gou , Zefeng Xia , Zhongmin Gao , Mohammed Bensellam , Will Hughes , Jackie Lau , Lei Zhang , Chi Kin Ip , Ronaldo Enriquez , Hanyu Gao , Qiao-Ping Wang , Qi Wu , Jody J Haigh , D Ross Laybutt , Paul Timpson , Herbert Herzog , Yan-Chuan Shi

XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice.

Diabetologia

Avec: Kailun Lee , Jeng Yie Chan , Cassandra Liang , Chi Kin Ip , Yan-Chuan Shi , Herbert Herzog , William E Hughes , Mohammed Bensellam , Viviane Delghingaro-Augusto , Mark E Koina , Christopher J Nolan , D Ross Laybutt

Complementary yet divergent effects of exercise and an exercise mimetic on microbiome in high-fat diet-induced obesity.

Physiological genomics

Avec: Josephine Yu , Neil A Youngson , D Ross Laybutt , Margaret J Morris , Sarah-Jane Leigh

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.

Diabetologia

Avec: Mohammed Bensellam , Yan-Chuan Shi , Jeng Yie Chan , D Ross Laybutt , Heeyoung Chae , Michel Abou-Samra , Evan G Pappas , Helen E Thomas , Patrick Gilon , Jean-Christophe Jonas

Phlda3 regulates beta cell survival during stress.

Scientific reports

Avec: Mohammed Bensellam , Jeng Yie Chan , Kailun Lee , Mugdha V Joglekar , Anandwardhan A Hardikar , Thomas Loudovaris , Helen E Thomas , Jean-Christophe Jonas , D Ross Laybutt

Loss-of-function of the long non-coding RNA A830019P07Rik in mice does not affect insulin expression and secretion.

Scientific reports

Avec: Claudiane Guay , Baroj Abdulkarim , Jennifer Y Tan , Gilles Dubuis , Sabine Rütti , David Ross Laybutt , Christian Widmann , Romano Regazzi , Ana Claudia Marques

Publisher Correction: Loss-of-function of the long non-coding RNA A830019P07Rik in mice does not affect insulin expression and secretion.

Scientific reports

Avec: Claudiane Guay , Baroj Abdulkarim , Jennifer Y Tan , Gilles Dubuis , Sabine Rütti , David Ross Laybutt , Christian Widmann , Romano Regazzi , Ana Claudia Marques

Macrophage alterations in islets of obese mice linked to beta cell disruption in diabetes.

Diabetologia

Avec: Jeng Yie Chan , Kailun Lee , Emma L Maxwell , Cassandra Liang , D Ross Laybutt

Deletion distal to the PAX6 coding region reveals a novel basis for familial cosegregation of aniridia and diabetes mellitus.

Diabetes research and clinical practice

Avec: Gemma C Macdonald , Stephanie E Hesselson , Jeng Yie Chan , Arthur B Jenkins , D Ross Laybutt , Daniel Hesselson , Lesley V Campbell

Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes.

Molecular metabolism

Avec: Chieh-Hsin Yang , Danise Ann-Onda , Xuzhu Lin , Stacey Fynch , Shaktypreya Nadarajah , Evan G Pappas , Xin Liu , John W Scott , Jonathan S Oakhill , Sandra Galic , Yanchuan Shi , Alba Moreno-Asso , Cassandra Smith , Thomas Loudovaris , Itamar Levinger , Decio L Eizirik , D Ross Laybutt , Herbert Herzog , Helen E Thomas , Kim Loh

Concurrent betaine administration enhances exercise-induced improvements to glucose handling in obese mice.

Nutrition, metabolism, and cardiovascular diseases : NMCD

Avec: Josephine Yu , D Ross Laybutt , Neil A Youngson , Margaret J Morris

Tau suppresses microtubule-regulated pancreatic insulin secretion.

Molecular psychiatry

Avec: Salvatore P Mangiafico , Qing-Zhang Tuo , Xiao-Lan Li , Yu Liu , Christian Haralambous , Xu-Long Ding , Scott Ayton , Qing Wang , D Ross Laybutt , Jeng Yie Chan , Xiang Zhang , Cameron Kos , Helen E Thomas , Thomas Loudovaris , Chieh-Hsin Yang , Christos N Joannides , Benjamin J Lamont , Lunzhi Dai , Hai-Huai He , Biao Dong , Sofianos Andrikopoulos , Ashley I Bush , Peng Lei

A fluorescent timer reporter enables sorting of insulin secretory granules by age.

The Journal of biological chemistry

Avec: Belinda Yau , Lori Hays , Cassandra Liang , D Ross Laybutt , Helen E Thomas , Jenny E Gunton , Lindy Williams , Wayne J Hawthorne , Peter Thorn , Christopher J Rhodes , Melkam A Kebede

Heparan sulfate proteoglycans in beta cells provide a critical link between endoplasmic reticulum stress, oxidative stress and type 2 diabetes.

PloS one

Avec: Sarita Dhounchak , Sarah K Popp , Debra J Brown , D Ross Laybutt , Trevor J Biden , Stefan R Bornstein , Christopher R Parish , Charmaine J Simeonovic

Iron chelation increases beige fat differentiation and metabolic activity, preventing and treating obesity.

Scientific reports

Avec: Mojgan Nazari , Kenneth W Ho , Natasha Langley , Kuan M Cha , Raymond Kodsi , Mawson Wang , D Ross Laybutt , Kim Cheng , Rebecca A Stokes , Michael M Swarbrick , Jenny E Gunton

Transcriptome analysis of islets from diabetes-resistant and diabetes-prone obese mice reveals novel gene regulatory networks involved in beta-cell compensation and failure.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Jeng Yie Chan , Mohammed Bensellam , Ruby C Y Lin , Cassandra Liang , Kailun Lee , Jean-Christophe Jonas , D Ross Laybutt

The Role of Fatty Acid Signaling in Islet Beta-Cell Adaptation to Normal Pregnancy.

Frontiers in endocrinology

Avec: Jee-Hye Kim , Viviane Delghingaro-Augusto , Jeng Yie Chan , D Ross Laybutt , Joseph Proietto , Christopher J Nolan

Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide.

American journal of physiology. Endocrinology and metabolism

Avec: Josephine Yu , David Ross Laybutt , Lynn-Jee Kim , Lake-Ee Quek , Lindsay E Wu , Margaret J Morris , Neil A Youngson

Réseau de co-auteurs

Jeng Yie Chan 8 collaborations

Mohammed Bensellam 6 collaborations

Kailun Lee 5 collaborations

Helen E Thomas 5 collaborations

Jean-Christophe Jonas 4 collaborations

Cassandra Liang 4 collaborations

Jenny E Gunton 3 collaborations

Herbert Herzog 3 collaborations

Yan-Chuan Shi 3 collaborations

Josephine Yu 3 collaborations

Neil A Youngson 3 collaborations

Margaret J Morris 3 collaborations

Thomas Loudovaris 3 collaborations

David Ross Laybutt 3 collaborations

Wayne J Hawthorne 2 collaborations

Rebecca A Stokes 2 collaborations

Michael M Swarbrick 2 collaborations

Kim Loh 2 collaborations

Chi Kin Ip 2 collaborations

Viviane Delghingaro-Augusto 2 collaborations

Christopher J Nolan 2 collaborations

Evan G Pappas 2 collaborations

Claudiane Guay 2 collaborations

Baroj Abdulkarim 2 collaborations

Jennifer Y Tan 2 collaborations

Gilles Dubuis 2 collaborations

Sabine Rütti 2 collaborations

Christian Widmann 2 collaborations

Romano Regazzi 2 collaborations

Ana Claudia Marques 2 collaborations

Chieh-Hsin Yang 2 collaborations

Amit Lalwani 1 collaboration

Joanna Warren 1 collaboration

David Liuwantara 1 collaboration

Philip J O'Connell 1 collaboration

Frank J Gonzalez 1 collaboration

Jennifer Chen 1 collaboration

Maria E Craig 1 collaboration

Cecile King 1 collaboration

Chenxu Yan 1 collaboration

Tianshu Zeng 1 collaboration

Max Nobis 1 collaboration

Luoning Gou 1 collaboration

Zefeng Xia 1 collaboration

Zhongmin Gao 1 collaboration

Will Hughes 1 collaboration

Jackie Lau 1 collaboration

Lei Zhang 1 collaboration

Ronaldo Enriquez 1 collaboration

Hanyu Gao 1 collaboration

Qiao-Ping Wang 1 collaboration

Qi Wu 1 collaboration

Jody J Haigh 1 collaboration

Paul Timpson 1 collaboration

William E Hughes 1 collaboration

Mark E Koina 1 collaboration

Sarah-Jane Leigh 1 collaboration

Heeyoung Chae 1 collaboration

Michel Abou-Samra 1 collaboration

Patrick Gilon 1 collaboration

Mugdha V Joglekar 1 collaboration

Anandwardhan A Hardikar 1 collaboration

Emma L Maxwell 1 collaboration

Gemma C Macdonald 1 collaboration

Stephanie E Hesselson 1 collaboration

Arthur B Jenkins 1 collaboration

Daniel Hesselson 1 collaboration

Lesley V Campbell 1 collaboration

Danise Ann-Onda 1 collaboration

Xuzhu Lin 1 collaboration

Stacey Fynch 1 collaboration

Shaktypreya Nadarajah 1 collaboration

Xin Liu 1 collaboration

John W Scott 1 collaboration

Jonathan S Oakhill 1 collaboration

Sandra Galic 1 collaboration

Yanchuan Shi 1 collaboration

Alba Moreno-Asso 1 collaboration

Cassandra Smith 1 collaboration

Itamar Levinger 1 collaboration

Decio L Eizirik 1 collaboration

Salvatore P Mangiafico 1 collaboration

Qing-Zhang Tuo 1 collaboration

Xiao-Lan Li 1 collaboration

Yu Liu 1 collaboration

Christian Haralambous 1 collaboration

Xu-Long Ding 1 collaboration

Scott Ayton 1 collaboration

Qing Wang 1 collaboration

Xiang Zhang 1 collaboration

Cameron Kos 1 collaboration

Christos N Joannides 1 collaboration

Benjamin J Lamont 1 collaboration

Lunzhi Dai 1 collaboration

Hai-Huai He 1 collaboration

Biao Dong 1 collaboration

Sofianos Andrikopoulos 1 collaboration

Ashley I Bush 1 collaboration

Peng Lei 1 collaboration

Belinda Yau 1 collaboration

Lori Hays 1 collaboration

Lindy Williams 1 collaboration

Peter Thorn 1 collaboration

Christopher J Rhodes 1 collaboration

Melkam A Kebede 1 collaboration

Sarita Dhounchak 1 collaboration

Sarah K Popp 1 collaboration

Debra J Brown 1 collaboration

Trevor J Biden 1 collaboration

Stefan R Bornstein 1 collaboration

Christopher R Parish 1 collaboration

Charmaine J Simeonovic 1 collaboration

Mojgan Nazari 1 collaboration

Kenneth W Ho 1 collaboration

Natasha Langley 1 collaboration

Kuan M Cha 1 collaboration

Raymond Kodsi 1 collaboration

Mawson Wang 1 collaboration

Kim Cheng 1 collaboration

Ruby C Y Lin 1 collaboration

Jee-Hye Kim 1 collaboration

Joseph Proietto 1 collaboration

Lynn-Jee Kim 1 collaboration

Lake-Ee Quek 1 collaboration

Lindsay E Wu 1 collaboration