Concordance in parent and offspring cortico-basal ganglia white matter connectivity varies by parental history of major depressive disorder and early parental care.
Adolescent
Adult
Basal Ganglia
/ diagnostic imaging
Cerebral Cortex
/ diagnostic imaging
Child
Child of Impaired Parents
Depressive Disorder, Major
/ diagnostic imaging
Diffusion Tensor Imaging
Female
Humans
Male
Middle Aged
Neural Pathways
/ diagnostic imaging
Parent-Child Relations
Risk Factors
White Matter
/ diagnostic imaging
Young Adult
DTI
concordance
major depression
parent–offspring bonding
social cognition
Journal
Social cognitive and affective neuroscience
ISSN: 1749-5024
Titre abrégé: Soc Cogn Affect Neurosci
Pays: England
ID NLM: 101288795
Informations de publication
Date de publication:
08 10 2020
08 10 2020
Historique:
received:
17
03
2020
revised:
23
06
2020
accepted:
18
08
2020
entrez:
8
10
2020
pubmed:
9
10
2020
medline:
30
6
2021
Statut:
ppublish
Résumé
Social behavior is transmitted cross-generationally through coordinated behavior within attachment bonds. Parental depression and poor parental care are major risks for disruptions of such coordination and are associated with offspring's psychopathology and interpersonal dysfunction. Given the key role of the cortico-basal ganglia (CBG) circuits in social communication, we examined similarities (concordance) of parent-offspring CBG white matter (WM) connections and how parental history of major depressive disorder (MDD) and early parental care moderate these similarities. We imaged 44 parent-offspring dyads and investigated WM connections between basal-ganglia seeds and selected regions in temporal cortex using diffusion tensor imaging (DTI) tractography. We found significant concordance in parent-offspring strength of CBG WM connections, moderated by parental lifetime-MDD and care. The results showed diminished neural concordance among dyads with a depressed parent and that better parental care predicted greater concordance, which also provided a protective buffer against attenuated concordance among dyads with a depressed parent. Our findings provide the first neurobiological evidence of concordance between parents-offspring in WM tracts and that concordance is diminished in families where parents have lifetime-MDD. This disruption may be a risk factor for intergenerational transmission of psychopathology. Findings emphasize the long-term role of early caregiving in shaping the neural concordance among at-risk and affected dyads.
Identifiants
pubmed: 33031555
pii: 5896902
doi: 10.1093/scan/nsaa118
pmc: PMC7543940
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
889-903Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
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