COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment.

Antibodies, Monoclonal, Humanized / therapeutic use Aphasia / etiology Brain Diseases / drug therapy COVID-19 / complications Cytokine Release Syndrome / drug therapy Female Humans Middle Aged SARS-CoV-2 COVID-19 Drug Treatment
Cytokines Delirium Encephalitis Immunotherapy Neurological SARS-COV-2

Journal

Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498

Informations de publication

Date de publication:
15 12 2020
Historique:
received: 27 08 2020
revised: 17 09 2020
accepted: 18 09 2020
pubmed: 9 10 2020
medline: 15 12 2020
entrez: 8 10 2020
Statut: ppublish

Résumé

Encephalopathy is emerging as a recurrent complication of COVID-19 yet remains poorly characterized. We report the case of a middle-aged woman with COVID-19-related encephalopathy presenting as expressive aphasia and inattentiveness, subsequently progressing to agitation and marked confusion. Brain MRI and CSF analysis were unremarkable, while EEG showed slowing with frontal sharp waves. Neuropsychiatric symptoms resolved following treatment with tocilizumab. CNS involvement in COVID-19 may present as a subacute encephalopathy characterized by prominent frontal lobe dysfunction, with language disturbances as first neurological manifestation. Future studies should further investigate the role of tocilizumab in treating COVID-19-related encephalopathy.

Identifiants

DOI: 10.1016/j.jneuroim.2020.577400 PMID: 33032013 PMC: PMC7513756
pubmed: 33032013
pii: S0165-5728(20)30583-X
doi: 10.1016/j.jneuroim.2020.577400
pmc: PMC7513756
pii:
doi:

Substances chimiques

Antibodies, Monoclonal, Humanized 0
tocilizumab I031V2H011

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

577400

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

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Auteurs

Lorenzo Muccioli (L)

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.

Umberto Pensato (U)

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.

Ilaria Cani (I)

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.

Luca Guerra (L)

Infectious Diseases Unit, AOSP and AUSL Bologna, Bologna, Italy.

Federica Provini (F)

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna, Full Member of the ERN EpiCARE, Bologna, Italy.

Giorgio Bordin (G)

Piccole Figlie Hospital, Parma, Italy.

Luca Albini Riccioli (LA)

IRCCS Istituto delle Scienze Neurologiche di Bologna, Full Member of the ERN EpiCARE, Bologna, Italy.

Raffaele Lodi (R)

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna, Full Member of the ERN EpiCARE, Bologna, Italy.

Paolo Tinuper (P)

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna, Full Member of the ERN EpiCARE, Bologna, Italy.

Francesca Bisulli (F)

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna, Full Member of the ERN EpiCARE, Bologna, Italy. Electronic address: francesca.bisulli@unibo.it.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › COVID-19-related encephalopathy presenting...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles du langage › Troubles de la parole › Aphasie › COVID-19-related encephalopathy presenting...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › COVID-19-related encephalopathy presenting...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › COVID-19-related encephalopathy presenting...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Choc › Syndrome de réponse inflammatoire généralisée › Syndrome de libération de cytokines › COVID-19-related encephalopathy presenting...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › COVID-19-related encephalopathy presenting...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › COVID-19-related encephalopathy presenting...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › COVID-19-related encephalopathy presenting...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitements médicamenteux de la COVID-19 › COVID-19-related encephalopathy presenting...