AQP4 autoantibodies in patients with idiopathic normal pressure hydrocephalus.
Aquaporin 4
Autoantibodies
Glymphatic system
Idiopathic normal pressure hydrocephalus
Neuromyelitis optica
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
received:
04
08
2020
revised:
14
09
2020
accepted:
24
09
2020
pubmed:
9
10
2020
medline:
17
12
2020
entrez:
8
10
2020
Statut:
ppublish
Résumé
Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder with unknown etiology. A selective depletion of aquaporin 4 (AQP4) has been shown in iNPH patients. We collected serum and cerebrospinal fluid (CSF) from 43 iNPH patients and 35 with other neurodegenerative conditions, and serum from 43 healthy subjects. All samples were tested for AQP4-IgG/IgA/IgM antibodies using a live cell-based assay. No patients or controls had serum/CSF AQP4-IgG/IgA. One/43 iNPH patient and 0/43 controls tested positive for serum AQP4-IgM. The AQP4-IgM-positive iNPH patient had no clinico-radiological distinctive features. AQP4 antibodies are unlikely to play a role in iNPH pathogenesis.
Identifiants
pubmed: 33032017
pii: S0165-5728(20)30526-9
doi: 10.1016/j.jneuroim.2020.577407
pii:
doi:
Substances chimiques
AQP4 protein, human
0
Aquaporin 4
0
Autoantibodies
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577407Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.