The prevalence and immunological features of anti-glomerular basement membrane antibody in patients with HIV.
AIDS
Anti-GBM antibodies
Antigen
HIV
IgG subclasses
Journal
BMC nephrology
ISSN: 1471-2369
Titre abrégé: BMC Nephrol
Pays: England
ID NLM: 100967793
Informations de publication
Date de publication:
08 10 2020
08 10 2020
Historique:
received:
11
12
2019
accepted:
02
10
2020
entrez:
9
10
2020
pubmed:
10
10
2020
medline:
12
10
2021
Statut:
epublish
Résumé
Anti-glomerular basement membrane disease (GBM) is an autoimmune disease caused by the deposition of circulating anti-GBM antibodies. Non-collagen region of α3 chain of type IV collagen (α3(IV)NC1) is one of the main target antigens, in which E In this study, the positive rate of the anti-GBM antibodies in HIV and the immunological characteristics of the target antigens were clarified. A total of 93 HIV patients diagnosed in Beijing Youan Hospital from November 2017 to January 2018 were included. Enzyme-linked immunosorbent assay was used to measure the serum IgG autoantibodies specifically against GBM in these patients, as well as their subtypes and antigen spectra. It was found that five out of the 93 patients with HIV had low to moderate levels of anti-GBM antibodies. However, these patients presented with no clinical manifestation of any kidney injury or pulmonary hemorrhages. Compared with HIV patients with negative antibodies, there were no significant differences in gender, age, CD4 These data suggest a distinct immunological profile of anti-GBM antibodies in patients with HIV, and might explain the non-pathogenic features of HIV associated anti-GBM antibodies.
Sections du résumé
BACKGROUND
Anti-glomerular basement membrane disease (GBM) is an autoimmune disease caused by the deposition of circulating anti-GBM antibodies. Non-collagen region of α3 chain of type IV collagen (α3(IV)NC1) is one of the main target antigens, in which E
OBJECTIVES
In this study, the positive rate of the anti-GBM antibodies in HIV and the immunological characteristics of the target antigens were clarified.
METHODS
A total of 93 HIV patients diagnosed in Beijing Youan Hospital from November 2017 to January 2018 were included. Enzyme-linked immunosorbent assay was used to measure the serum IgG autoantibodies specifically against GBM in these patients, as well as their subtypes and antigen spectra.
RESULTS
It was found that five out of the 93 patients with HIV had low to moderate levels of anti-GBM antibodies. However, these patients presented with no clinical manifestation of any kidney injury or pulmonary hemorrhages. Compared with HIV patients with negative antibodies, there were no significant differences in gender, age, CD4
CONCLUSION
These data suggest a distinct immunological profile of anti-GBM antibodies in patients with HIV, and might explain the non-pathogenic features of HIV associated anti-GBM antibodies.
Identifiants
pubmed: 33032537
doi: 10.1186/s12882-020-02087-y
pii: 10.1186/s12882-020-02087-y
pmc: PMC7545569
doi:
Substances chimiques
Autoantibodies
0
Epitopes
0
Immunoglobulin G
0
antiglomerular basement membrane antibody
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
429Subventions
Organisme : Innovative Research Group Project of the National Natural Science Foundation of China
ID : 81621092
Pays : International
Organisme : the Outstanding Young Scholar
ID : 81622009
Pays : International
Organisme : other programs
ID : 81330020, 81370801, 81870482
Pays : International
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