Bovine adapted transmissible mink encephalopathy is similar to L-BSE after passage through sheep with the VRQ/VRQ genotype but not VRQ/ARQ.
C-BSE
L-BSE
PRNP
PrPSc
Prion
Prion diseases
Sheep
TME
TSE
Transmissible mink encephalopathy
Transmissible spongiform encephalopathies
Journal
BMC veterinary research
ISSN: 1746-6148
Titre abrégé: BMC Vet Res
Pays: England
ID NLM: 101249759
Informations de publication
Date de publication:
08 Oct 2020
08 Oct 2020
Historique:
received:
26
05
2020
accepted:
05
10
2020
entrez:
9
10
2020
pubmed:
10
10
2020
medline:
1
5
2021
Statut:
epublish
Résumé
Transmissible mink encephalopathy (TME) is a fatal neurologic disease of farmed mink. Evidence indicates that TME and L-BSE are similar and may be linked in some outbreaks of TME. We previously transmitted bovine adapted TME (bTME) to sheep. The present study compared ovine passaged bTME (o-bTME) to C-BSE and L-BSE in transgenic mice expressing wild type bovine prion protein (TgBovXV). To directly compare the transmission efficiency of all prion strains in this study, we considered the attack rates and mean incubation periods. Additional methods for strain comparison were utilized including lesion profiles, fibril stability, and western blotting. Sheep donor genotype elicited variable disease phenotypes in bovinized mice. Inoculum derived from a sheep with the VRQ/VRQ genotype (o-bTME Our findings provide insight on how sheep host genotype modulates strain genesis and influences interspecies transmission characteristics. Given that the transmission efficiencies of L-BSE and bTME are higher than C-BSE, coupled with previous reports of L-BSE transmission to mice expressing the human prion protein, continued monitoring for atypical BSE is advisable in order to prevent occurrences of interspecies transmission that may affect humans or other species.
Sections du résumé
BACKGROUND
BACKGROUND
Transmissible mink encephalopathy (TME) is a fatal neurologic disease of farmed mink. Evidence indicates that TME and L-BSE are similar and may be linked in some outbreaks of TME. We previously transmitted bovine adapted TME (bTME) to sheep. The present study compared ovine passaged bTME (o-bTME) to C-BSE and L-BSE in transgenic mice expressing wild type bovine prion protein (TgBovXV). To directly compare the transmission efficiency of all prion strains in this study, we considered the attack rates and mean incubation periods. Additional methods for strain comparison were utilized including lesion profiles, fibril stability, and western blotting.
RESULTS
RESULTS
Sheep donor genotype elicited variable disease phenotypes in bovinized mice. Inoculum derived from a sheep with the VRQ/VRQ genotype (o-bTME
CONCLUSIONS
CONCLUSIONS
Our findings provide insight on how sheep host genotype modulates strain genesis and influences interspecies transmission characteristics. Given that the transmission efficiencies of L-BSE and bTME are higher than C-BSE, coupled with previous reports of L-BSE transmission to mice expressing the human prion protein, continued monitoring for atypical BSE is advisable in order to prevent occurrences of interspecies transmission that may affect humans or other species.
Identifiants
pubmed: 33032590
doi: 10.1186/s12917-020-02611-0
pii: 10.1186/s12917-020-02611-0
pmc: PMC7545885
doi:
Substances chimiques
PrPC Proteins
0
Prion Proteins
0
Prions
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
383Références
PLoS One. 2011 Jan 14;6(1):e15839
pubmed: 21264286
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19105-10
pubmed: 17142317
Vet Res. 2015 Jul 13;46:81
pubmed: 26169916
J Gen Virol. 2004 Aug;85(Pt 8):2471-2478
pubmed: 15269389
Nat Med. 1998 Oct;4(10):1157-65
pubmed: 9771749
Sci Rep. 2020 Feb 21;10(1):3148
pubmed: 32081886
J Virol. 2011 Feb;85(3):1174-81
pubmed: 21084466
Emerg Infect Dis. 2020 Jun;26(6):1130-1139
pubmed: 32441630
Vet Pathol. 2019 May;56(3):409-417
pubmed: 30558513
Philos Trans R Soc Lond B Biol Sci. 1994 Mar 29;343(1306):405-11
pubmed: 7913758
Vet Rec. 1997 Aug 9;141(6):137-40
pubmed: 9280041
J Gen Virol. 1991 Mar;72 ( Pt 3):589-94
pubmed: 1826023
Nature. 1997 Oct 2;389(6650):448-50, 526
pubmed: 9333232
J Virol. 2008 Apr;82(7):3697-701
pubmed: 18234793
Virology. 1998 Nov 25;251(2):297-301
pubmed: 9837794
Vet Res. 2012 Jul 02;43:55
pubmed: 22748008
J Virol. 2007 Jan;81(2):835-43
pubmed: 17079295
PLoS Pathog. 2012 Feb;8(2):e1002522
pubmed: 22319450
PLoS Pathog. 2007 Mar;3(3):e31
pubmed: 17352534
Emerg Infect Dis. 2011 Sep;17(9):1636-44
pubmed: 21888788
J Virol. 2008 Nov;82(22):11197-207
pubmed: 18768980
Proc Natl Acad Sci U S A. 2019 Dec 16;:
pubmed: 31843908
Sci Rep. 2020 Jan 8;10(1):19
pubmed: 31913327
Neuropathol Appl Neurobiol. 2007 Aug;33(4):373-94
pubmed: 17617870
Proc Natl Acad Sci U S A. 1990 Apr;87(7):2476-80
pubmed: 1969635
Rev Sci Tech. 1992 Jun;11(2):539-50
pubmed: 1535524
Vet Res. 2016 Nov 8;47(1):112
pubmed: 27825366
Br Med Bull. 2003;66:99-108
pubmed: 14522852
PLoS One. 2012;7(8):e43060
pubmed: 22916207
Vet Rec. 1997 Jan 18;140(3):59-63
pubmed: 9023905
J Gen Virol. 1991 Mar;72 ( Pt 3):595-603
pubmed: 1672371
J Gen Virol. 2015 Dec;96(12):3703-3714
pubmed: 26611906
Emerg Infect Dis. 2007 Dec;13(12):1887-94
pubmed: 18258040
PLoS Pathog. 2011 Mar;7(3):e1001317
pubmed: 21437239
J Comp Pathol. 1973 Jan;83(1):29-40
pubmed: 4199908
Science. 1968 Jul 26;161(3839):388-9
pubmed: 5661299
J Gen Virol. 1992 Feb;73 ( Pt 2):329-34
pubmed: 1531675
J Neurosci. 2007 Jun 27;27(26):6965-71
pubmed: 17596445
Nature. 1997 Oct 2;389(6650):498-501
pubmed: 9333239
Vet Rec. 1987 Oct 31;121(18):419-20
pubmed: 3424605
Arch Virol Suppl. 2000;(16):75-86
pubmed: 11214936
J Gen Virol. 1994 May;75 ( Pt 5):989-95
pubmed: 7909834
J Comp Pathol. 1968 Jul;78(3):301-11
pubmed: 4970192
Front Vet Sci. 2019 Nov 29;6:430
pubmed: 31850385
Sci Rep. 2020 Mar 19;10(1):5042
pubmed: 32193445
BMC Vet Res. 2018 Mar 9;14(1):80
pubmed: 29523205
Cell. 2008 Sep 5;134(5):757-68
pubmed: 18775309
BMC Vet Res. 2008 Jun 10;4:19
pubmed: 18544152
J Gen Virol. 2011 Jun;92(Pt 6):1482-1491
pubmed: 21270287
Protein Sci. 2001 Apr;10(4):854-63
pubmed: 11274476
J Infect Dis. 1965 Oct;115(4):387-92
pubmed: 5891240
Nature. 1996 Oct 24;383(6602):685-90
pubmed: 8878476
Vet Res. 2008 Jul-Aug;39(4):32
pubmed: 18284909
J Histochem Cytochem. 2006 Oct;54(10):1087-94
pubmed: 16735593
Vet Pathol. 2006 Mar;43(2):118-26
pubmed: 16537929
Emerg Infect Dis. 2008 Feb;14(2):298-300
pubmed: 18258124
Vet Rec. 1991 Mar 2;128(9):199-203
pubmed: 1823120
Prion. 2013 Mar-Apr;7(2):99-108
pubmed: 23357828
J Comp Pathol. 2013 Jul;149(1):113-8
pubmed: 23273583
J Neuropathol Exp Neurol. 2010 May;69(5):483-97
pubmed: 20418778
Emerg Infect Dis. 2008 Dec;14(12):1898-901
pubmed: 19046515
J Gen Virol. 1996 Oct;77 ( Pt 10):2669-73
pubmed: 8887505