Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection.
Adolescent
Adult
Animals
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Chemokine CXCL1
/ pharmacology
Humans
Inflammation
/ immunology
Interleukin-17
/ immunology
Mice
Mice, Inbred C57BL
Middle Aged
Nasal Mucosa
/ immunology
Neutrophil Activation
Neutrophils
/ drug effects
Respiratory Syncytial Virus Infections
/ immunology
Respiratory Syncytial Viruses
Tumor Necrosis Factor-alpha
/ immunology
Young Adult
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
09 10 2020
09 10 2020
Historique:
received:
17
01
2020
revised:
30
06
2020
accepted:
19
08
2020
entrez:
9
10
2020
pubmed:
10
10
2020
medline:
29
10
2020
Statut:
ppublish
Résumé
The variable outcome of viral exposure is only partially explained by known factors. We administered respiratory syncytial virus (RSV) to 58 volunteers, of whom 57% became infected. Mucosal neutrophil activation before exposure was highly predictive of symptomatic RSV disease. This was associated with a rapid, presymptomatic decline in mucosal interleukin-17A (IL-17A) and other mediators. Conversely, those who resisted infection showed presymptomatic activation of IL-17- and tumor necrosis factor-related pathways. Vulnerability to infection was not associated with baseline microbiome but was reproduced in mice by preinfection chemokine-driven airway recruitment of neutrophils, which caused enhanced disease mediated by pulmonary CD8
Identifiants
pubmed: 33033192
pii: 370/6513/eaba9301
doi: 10.1126/science.aba9301
pmc: PMC7613218
mid: EMS145175
pii:
doi:
Substances chimiques
Chemokine CXCL1
0
Interleukin-17
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/T50256X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0902266
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 087805
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 090382
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R005982/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R502121/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 109058
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020, American Association for the Advancement of Science.
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