Surgical Site Infections after glioblastoma surgery: results of a multicentric retrospective study.

Glioblastoma / surgery Humans Neoplasm Recurrence, Local Retrospective Studies Risk Factors Surgical Wound Infection / epidemiology
Glioblastoma Surgical site infection

Journal

Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 03 08 2020
accepted: 28 09 2020
pubmed: 10 10 2020
medline: 26 11 2021
entrez: 9 10 2020
Statut: ppublish

Résumé

The effects of surgical site infections (SSI) after glioblastoma surgery on patient outcomes are understudied. The aim of this retrospective multicenter study was to evaluate the impact of SSI on the survival of glioblastoma patients. Data from SSI cases after glioblastoma surgeries between 2009 and 2016 were collected from 14 French neurosurgical centers. Collected data included patient demographics, previous medical history, risk factors, details of the surgical procedure, radiotherapy/chemotherapy, infection characteristics, and infection management. Similar data were collected from gender- and age-paired control individuals. We used the medical records of 77 SSI patients and 58 control individuals. 13 were excluded. Our analyses included data from 64 SSI cases and 58 non-infected glioblastoma patients. Infections occurred after surgery for primary tumors in 38 cases (group I) and after surgery for a recurrent tumor in 26 cases (group II). Median survival was 381, 633, and 547 days in patients of group I, group II, and the control group, respectively. Patients in group I had significantly shorter survival compared to the other two groups (p < 0.05). The one-year survival rate of patients who developed infections after surgery for primary tumors was 50%. Additionally, we found that SSIs led to postoperative treatment discontinuation in 30% of the patients. Our findings highlighted the severity of SSIs after glioblastoma surgery, as they significantly affect patient survival. The establishment of preventive measures, as well as guidelines for the management of SSIs, is of high clinical importance.

Sections du résumé

BACKGROUND BACKGROUND
The effects of surgical site infections (SSI) after glioblastoma surgery on patient outcomes are understudied. The aim of this retrospective multicenter study was to evaluate the impact of SSI on the survival of glioblastoma patients.
METHODS METHODS
Data from SSI cases after glioblastoma surgeries between 2009 and 2016 were collected from 14 French neurosurgical centers. Collected data included patient demographics, previous medical history, risk factors, details of the surgical procedure, radiotherapy/chemotherapy, infection characteristics, and infection management. Similar data were collected from gender- and age-paired control individuals.
RESULTS RESULTS
We used the medical records of 77 SSI patients and 58 control individuals. 13 were excluded. Our analyses included data from 64 SSI cases and 58 non-infected glioblastoma patients. Infections occurred after surgery for primary tumors in 38 cases (group I) and after surgery for a recurrent tumor in 26 cases (group II). Median survival was 381, 633, and 547 days in patients of group I, group II, and the control group, respectively. Patients in group I had significantly shorter survival compared to the other two groups (p < 0.05). The one-year survival rate of patients who developed infections after surgery for primary tumors was 50%. Additionally, we found that SSIs led to postoperative treatment discontinuation in 30% of the patients.
DISCUSSION CONCLUSIONS
Our findings highlighted the severity of SSIs after glioblastoma surgery, as they significantly affect patient survival. The establishment of preventive measures, as well as guidelines for the management of SSIs, is of high clinical importance.

Identifiants

DOI: 10.1007/s15010-020-01534-0 PMID: 33034890
pubmed: 33034890
doi: 10.1007/s15010-020-01534-0
pii: 10.1007/s15010-020-01534-0
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

267-275

Références

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Auteurs

Henri Salle (H)

Neurochirurgie, CHU de Limoges, Limoges, France. henrisalle1@gmail.com.
CAPTuR, EA 3842, Université de Limoges, Limoges, France. henrisalle1@gmail.com.
ORCID: 0000-0002-1719-7183

Elise Deluche (E)

Oncologie médicale, CHU de Limoges, Limoges, France.

Elodie Couvé-Deacon (E)

Hygiène, CHU de Limoges, Limoges, France.

Anne-Claire Beaujeux (AC)

Neurochirurgie, CHU de Limoges, Limoges, France.

Johan Pallud (J)

Neurochirurgie, GHU Paris - Hôpital Sainte-Anne, Paris, France.
IMA-BRAIN, UMR1266, Inserm, Paris, France.

Alexandre Roux (A)

Neurochirurgie, GHU Paris - Hôpital Sainte-Anne, Paris, France.
IMA-BRAIN, UMR1266, Inserm, Paris, France.

Arnaud Dagain (A)

Neurochirurgie, BCRM Toulon, HIA Sainte-Anne, Toulon, France.

Amaury de Barros (A)

Neurochirurgie, CHU de Toulouse, Hopital Pierre-Paul Riquet, Toulouse, France.

Jimmy Voirin (J)

Neurochirurgie, Hôpitaux Civils de Colmar, Colmar, France.
Neurochirurgie, CHU de Strasbourg, Strasbourg, France.

Romuald Seizeur (R)

Neurochirurgie, Hôpital de La Cavale Blanche, CHU de Brest, Brest, France.
Université de BREST, LaTIM INSERM UMR 1101, Brest, France.

Houda Belmabrouk (H)

Neurochirurgie, Hôpital de La Cavale Blanche, CHU de Brest, Brest, France.

Leslie Lemnos (L)

Neurochirurgie, CHU de Limoges, Limoges, France.

Evelyne Emery (E)

Neurochirurgie, CHU Caen Normandie, Caen, France.
Université CAEN Normandie, Inserm U 12 37, Cycéron, Caen, France.

Marie-Jeanne Fotso (MJ)

Neurochirurgie, CHU de Saint-Etienne, Saint-Etienne, France.

Julien Engelhardt (J)

Neurochirurgie, CHU de Bordeaux, Bordeaux, France.

Vincent Jecko (V)

Neurochirurgie, CHU de Bordeaux, Bordeaux, France.
INCIA, UMR 5287, Université de Bordeaux, CNRS, Bordeaux, France.

Ilyess Zemmoura (I)

Neurochirurgie, CHU de Tours, Tours, France.
iBrain, UMR 1253, Université de Tours, Inserm, Tours, France.

Tuan Le Van (T)

Neurochirurgie, CHU de Dijon, Dijon, France.

Moncef Berhouma (M)

Neurochirurgie, CHU de Lyon, Hôpital Neurologique Pierre Wertheimer, Lyon, France.
Creatis Laboratory, , CNRS UMR 5220, INSERM U1206, Université Lyon 1/INSA, Lyon, France.

Hélène Cebula (H)

Neurochirurgie, CHU de Strasbourg, Strasbourg, France.

Matthieu Peyre (M)

Neurochirurgie, APHP, Groupe Hospitalier Pitié Salpêtrière, Paris, France.
Genetics and Development of Brain Tumors - CRICM INSERM U1127 CNRS UMR 7225, Paris, France.

Pierre-Marie Preux (PM)

Centre d'Epidémiologie, CHU de Limoges, de Biostatistiques Et de Méthodologie de La Recherche CEBIMER, Limoges, France.

François Caire (F)

Neurochirurgie, CHU de Limoges, Limoges, France.
XLIM, UMR 7252, Université de Limoges, CNRS, Limoges, France.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Surgical Site Infections after glioblastoma...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Surgical Site Infections after glioblastoma...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Surgical Site Infections after glioblastoma...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Surgical Site Infections after glioblastoma...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Surgical Site Infections after glioblastoma...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Infection de plaie opératoire › Surgical Site Infections after glioblastoma...