Hold your needles in women with recurrent pregnancy losses with or without hereditary thrombophilia: Meta-analysis and review of the literature.
Abortion, Habitual
/ blood
Anticoagulants
/ administration & dosage
Female
Heparin, Low-Molecular-Weight
/ administration & dosage
Humans
Live Birth
Needles
Odds Ratio
Pregnancy
Pregnancy Complications, Hematologic
/ drug therapy
Publication Bias
Randomized Controlled Trials as Topic
Thrombophilia
/ drug therapy
Hereditary thrombophilia
LMWH
RPL
Journal
Journal of gynecology obstetrics and human reproduction
ISSN: 2468-7847
Titre abrégé: J Gynecol Obstet Hum Reprod
Pays: France
ID NLM: 101701588
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
20
08
2020
revised:
01
10
2020
accepted:
01
10
2020
pubmed:
10
10
2020
medline:
29
10
2021
entrez:
9
10
2020
Statut:
ppublish
Résumé
The use of antithrombotic prophylaxis in women with recurrent pregnancy losses (RPL) remains controversial. We performed meta-analysis of randomized controlled trials (RCTs) comparing low molecular weight heparin (LMWH) versus No LMWH in women with or without hereditary thrombophilia and RPL. Twelve RCTs met our inclusion criteria and 2298 women were included in this meta-analysis. Our primary end point was live birth and odds ratio (OR) for live birth are reported. In women with thrombophilia the benefit of LMWH on live birth is not significant but heterogeneity of the studies is significant (OR, 2.09; 95 % CI, 0.58-7.57; p = 0.26; I Hold your needles in women with RPL. Probably in some hereditary thrombophilic defects LMWH has a positive effect on OR for live birth.
Identifiants
pubmed: 33035720
pii: S2468-7847(20)30299-3
doi: 10.1016/j.jogoh.2020.101935
pii:
doi:
Substances chimiques
Anticoagulants
0
Heparin, Low-Molecular-Weight
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101935Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors report no declarations of interest.