Synthesis of Novel Chalcone-Based Phenothiazine Derivatives as Antioxidant and Anticancer Agents.
Hep-G2
MCF-7
antioxidant
chalcone
cytotoxicity
phenothiazine
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Oct 2020
06 Oct 2020
Historique:
received:
14
08
2020
revised:
22
09
2020
accepted:
05
10
2020
entrez:
10
10
2020
pubmed:
11
10
2020
medline:
20
5
2021
Statut:
epublish
Résumé
Based on reported results for the potential medicinal impact of phenothiazine core, as well as the chalcone skeleton that is widely present in many natural products, together with their reported bioactivities, the present work was aimed at combining both moieties in one molecular skeleton and to synthesize and characterize a novel series of chalone-based phenothiazine derivatives. For this purpose, 2-acetylphenothiazine was N-alkylated, followed by the Claisen-Schmidt reaction to produce the chalcones with good yield. Antioxidant activity, as evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, was assessed to determine if their antioxidant potential was comparable with ascorbic acid, and attributable to the phenothiazine core. Screening anticancer activities of the synthesized chalone-based phenothiazine derivatives against human breast cancer cell line MCF-7 cells, and human hepatocellular carcinoma HepG-2 cells, compared with standard drugs cisplatin and doxorubicin, was evaluated. The results revealed that compounds 4a
Identifiants
pubmed: 33036301
pii: molecules25194566
doi: 10.3390/molecules25194566
pmc: PMC7583060
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Antioxidants
0
Chalcones
0
Phenothiazines
0
phenothiazine
GS9EX7QNU6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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