Discovery and Targeting of the Signaling Controls of
ACVR1
BMP signaling
CYT-387
JAK
NAFLD
NASH
PNPLA3
fibrosis
momelotinib
rs2294918
stellate
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
07 10 2020
07 10 2020
Historique:
received:
16
07
2020
revised:
01
10
2020
accepted:
05
10
2020
entrez:
10
10
2020
pubmed:
11
10
2020
medline:
5
8
2021
Statut:
epublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are emerging worldwide epidemics, projected to become the leading cause of liver transplants. The strongest genetic risk factor for NAFLD/NASH susceptibility and progression is a single-nucleotide polymorphism (SNP) in the patatin-like phospholipase domain-containing 3 gene (
Identifiants
pubmed: 33036387
pii: cells9102247
doi: 10.3390/cells9102247
pmc: PMC7600576
pii:
doi:
Substances chimiques
PNPLA3 protein, mouse
EC 3.1.1.3
Phospholipases A2, Calcium-Independent
EC 3.1.1.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
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