Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist.
Animals
Antibodies, Bispecific
/ pharmacology
Apoptosis
/ drug effects
Cadherins
/ metabolism
Caspases
/ metabolism
Cell Line, Tumor
Colorectal Neoplasms
/ pathology
Humans
Liver
/ drug effects
Mice
Neoplasm Metastasis
Receptors, TNF-Related Apoptosis-Inducing Ligand
/ agonists
Remission Induction
Xenograft Model Antitumor Assays
Journal
Molecular cancer therapeutics
ISSN: 1538-8514
Titre abrégé: Mol Cancer Ther
Pays: United States
ID NLM: 101132535
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
31
03
2020
revised:
12
08
2020
accepted:
30
09
2020
pubmed:
11
10
2020
medline:
13
8
2021
entrez:
10
10
2020
Statut:
ppublish
Résumé
Activation of TRAILR2 has emerged as an important therapeutic concept in cancer treatment. TRAILR2 agonistic molecules have only had limited clinical success, to date, due either to lack of efficacy or hepatotoxicity. BI 905711 is a novel tetravalent bispecific antibody targeting both TRAILR2 and CDH17 and represents a novel liver-sparing TRAILR2 agonist specifically designed to overcome the disadvantages of previous strategies. Here, we show that BI 905711 effectively triggered apoptosis in a broad panel of CDH17-positive colorectal cancer tumor cells
Identifiants
pubmed: 33037135
pii: 1535-7163.MCT-20-0253
doi: 10.1158/1535-7163.MCT-20-0253
doi:
Substances chimiques
Antibodies, Bispecific
0
CDH17 protein, human
0
Cadherins
0
Receptors, TNF-Related Apoptosis-Inducing Ligand
0
TNFRSF10B protein, human
0
Caspases
EC 3.4.22.-
Banques de données
ClinicalTrials.gov
['NCT04137289']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
96-108Informations de copyright
©2020 American Association for Cancer Research.
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