Skeletal muscle microvascular perfusion responses to cuff occlusion and submaximal exercise assessed by contrast-enhanced ultrasound: The effect of age.
Adult
Age Factors
Aged
Ankle Brachial Index
/ methods
Blood Flow Velocity
/ physiology
Exercise
/ physiology
Female
Humans
Leg
/ blood supply
Male
Microcirculation
/ physiology
Middle Aged
Muscle, Skeletal
/ blood supply
Peripheral Arterial Disease
/ physiopathology
Regional Blood Flow
/ physiology
Reproducibility of Results
aging
blood flow
exercise
muscle perfusion
reactive hyperemia
vascular conductance
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
19
05
2020
revised:
22
08
2020
accepted:
28
08
2020
entrez:
10
10
2020
pubmed:
11
10
2020
medline:
20
8
2021
Statut:
ppublish
Résumé
Impairments in skeletal muscle microvascular function are frequently reported in patients with various cardiometabolic conditions for which older age is a risk factor. Whether aging per se predisposes the skeletal muscle to microvascular dysfunction is unclear. We used contrast-enhanced ultrasound (CEU) to compare skeletal muscle microvascular perfusion responses to cuff occlusion and leg exercise between healthy young (n = 12, 26 ± 3 years) and older (n = 12, 68 ± 7 years) adults. Test-retest reliability of CEU perfusion parameters was also assessed. Microvascular perfusion (microvascular volume × flow velocity) of the medial gastrocnemius muscle was measured before and immediately after: (a) 5-min of thigh-cuff occlusion, and (b) 5-min of submaximal intermittent isometric plantar-flexion exercise (400 N) using CEU. Whole-leg blood flow was measured using strain-gauge plethysmography. Repeated measures were obtained with a 15-min interval, and averaged responses were used for comparisons between age groups. There were no differences in post-occlusion whole-leg blood flow and muscle microvascular perfusion between young and older participants (p > .05). Similarly, total whole-leg blood flow during exercise and post-exercise peak muscle microvascular perfusion did not differ between groups (p > .05). The overall level of agreement between the test-retest measures of calf muscle perfusion was excellent for measurements taken at rest (intraclass correlation coefficient [ICC] 0.85), and in response to cuff occlusion (ICC 0.89) and exercise (ICC 0.95). Our findings suggest that healthy aging does not affect muscle perfusion responses to cuff-occlusion and submaximal leg exercise. CEU muscle perfusion parameters measured in response to these provocation tests are highly reproducible in both young and older adults.
Identifiants
pubmed: 33038050
doi: 10.14814/phy2.14580
pmc: PMC7547535
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14580Informations de copyright
© 2020 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
Références
Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3043-9
pubmed: 16861699
Med Sci Sports Exerc. 2017 Aug;49(8):1623-1630
pubmed: 28709153
Eur J Appl Physiol. 2018 Feb;118(2):249-260
pubmed: 29192355
JACC Cardiovasc Imaging. 2015 Aug;8(8):913-21
pubmed: 26189114
Exp Physiol. 2004 Jul;89(4):473-85
pubmed: 15131070
Am J Physiol Endocrinol Metab. 2014 Dec 15;307(12):E1097-104
pubmed: 25336524
Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1109-16
pubmed: 19633208
Am J Physiol Endocrinol Metab. 2016 Mar 15;310(6):E379-87
pubmed: 26714849
Dyn Med. 2002 Dec 19;1:2
pubmed: 12605712
J Am Coll Cardiol. 1994 Aug;24(2):471-6
pubmed: 8034885
Clin Physiol Funct Imaging. 2002 Sep;22(5):348-55
pubmed: 12487008
J Gerontol. 1992 May;47(3):B71-6
pubmed: 1573181
J Vasc Surg. 2016 Jan;63(1):148-53
pubmed: 25065582
J Vasc Endovasc Surg. 2017;2(1):
pubmed: 28691118
Radiology. 2008 May;247(2):482-9
pubmed: 18372453
Circulation. 1998 Feb 10;97(5):473-83
pubmed: 9490243
Interface Focus. 2011 Aug 6;1(4):520-39
pubmed: 22866229
Ultrasound Med Biol. 2015 Jan;41(1):26-34
pubmed: 25308937
Eur J Appl Physiol. 2012 Dec;112(12):3997-4013
pubmed: 22441829
FASEB J. 2010 Oct;24(10):4117-27
pubmed: 20547663
Open Cardiovasc Med J. 2010 Dec 23;4:302-12
pubmed: 21339899
J Appl Physiol (1985). 2007 Jan;102(1):63-71
pubmed: 16946027
Atherosclerosis. 2015 Jan;238(1):147-52
pubmed: 25485738
Invest Radiol. 2009 Nov;44(11):741-7
pubmed: 19809343
Acta Physiol (Oxf). 2016 Oct;218(2):98-111
pubmed: 27174490
Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H272-8
pubmed: 16183733
Eur J Radiol. 2012 Nov;81(11):3332-8
pubmed: 22285606
Echocardiography. 2017 Aug;34(8):1187-1194
pubmed: 28664576
Eur Radiol. 2007 Oct;17(10):2663-74
pubmed: 17453217
Physiol Rep. 2020 Oct;8(19):e14580
pubmed: 33038050
Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1755-61
pubmed: 20817826
Circulation. 2004 Feb 10;109(5):613-9
pubmed: 14769683
J Appl Physiol (1985). 2017 Jul 1;123(1):106-115
pubmed: 28385914
Angiology. 2006 Dec-2007 Jan;57(6):702-8
pubmed: 17235110
J Appl Physiol (1985). 2014 Apr 15;116(8):998-1005
pubmed: 24577061
J Appl Physiol (1985). 1997 Jan;82(1):63-9
pubmed: 9029199
Exp Physiol. 2013 Dec;98(12):1645-58
pubmed: 23995101
J Appl Physiol (1985). 2011 Jul;111(1):244-50
pubmed: 21512151
JACC Cardiovasc Imaging. 2008 May;1(3):343-50
pubmed: 19356447
PLoS One. 2017 Mar 8;12(3):e0172771
pubmed: 28273102
IEEE Trans Biomed Eng. 1975 Jan;22(1):25-9
pubmed: 1110089
J Appl Physiol (1985). 2008 Mar;104(3):655-64
pubmed: 18162481
J Appl Physiol (1985). 2006 Jan;100(1):178-85
pubmed: 16166239
Hum Biol. 1986 Oct;58(5):771-82
pubmed: 3804298
Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1425-H1433
pubmed: 30095999
J Physiol. 2008 Feb 15;586(4):1161-8
pubmed: 18063659
Eur J Appl Physiol. 2018 May;118(5):989-1001
pubmed: 29502172
J Appl Physiol (1985). 2005 Jun;98(6):2249-58
pubmed: 15661836
Eur J Appl Physiol. 2011 Aug;111(8):1889-900
pubmed: 21234593
J Appl Physiol (1985). 2000 Apr;88(4):1321-6
pubmed: 10749826
J Appl Physiol (1985). 2005 Apr;98(4):1286-96
pubmed: 15579568
J Am Soc Echocardiogr. 2009 May;22(5):478-85.e3
pubmed: 19450742
Exerc Sport Sci Rev. 2010 Oct;38(4):177-85
pubmed: 20871234
Acta Neuropathol. 1980;51(2):99-105
pubmed: 7435151
Clin Hemorheol Microcirc. 2011;49(1-4):137-49
pubmed: 22214685