[Fundamental aspects of oncogenesis].

Aspects fondamentaux du développement tumoral.

Journal

Bulletin du cancer
ISSN: 1769-6917
Titre abrégé: Bull Cancer
Pays: France
ID NLM: 0072416

Informations de publication

Date de publication:
Nov 2020
Historique:
received: 14 05 2020
revised: 13 07 2020
accepted: 12 08 2020
pubmed: 12 10 2020
medline: 20 11 2020
entrez: 11 10 2020
Statut: ppublish

Résumé

Tumorigenesis has traditionally been considered as a multi-step process involving the activation of oncogenes as well as the inactivation of tumor suppressor genes. However, the mechanisms driving cancer initiation and progression are not restricted to molecular alterations and instead should be viewed as a complex process that interfaces with the entire organism. This didactic review provides an integrated and global view of the key fundamental principles of cancer development.

Identifiants

pubmed: 33039132
pii: S0007-4551(20)30367-2
doi: 10.1016/j.bulcan.2020.08.004
pii:
doi:

Types de publication

Journal Article Review

Langues

fre

Sous-ensembles de citation

IM

Pagination

1148-1160

Informations de copyright

Copyright © 2020 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Auteurs

Julie Lemaire (J)

CHU de Lille, université Lille, CNRS, Inserm, UMR9020-UMR-S 1277, 59000 Lille, France.

Romain Larrue (R)

CHU de Lille, service de toxicologie et génopathies, 59000 Lille, France.

Michael Perrais (M)

CHU de Lille, université Lille, CNRS, Inserm, UMR9020-UMR-S 1277, 59000 Lille, France.

Christelle Cauffiez (C)

CHU de Lille, université Lille, CNRS, Inserm, UMR9020-UMR-S 1277, 59000 Lille, France.

Nicolas Pottier (N)

CHU de Lille, université Lille, CNRS, Inserm, UMR9020-UMR-S 1277, 59000 Lille, France; CHU de Lille, service de toxicologie et génopathies, 59000 Lille, France. Electronic address: nicolas.pottier@univ-lille.fr.

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Classifications MeSH