Role of Vascular Adaptation in Determining Systolic Blood Pressure in Young Adults.
cardiac output
hemodynamics
minimum forearm vascular resistance
peripheral vascular resistance
pulse pressure
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
09 04 2020
09 04 2020
Historique:
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
9
3
2021
Statut:
ppublish
Résumé
Background Two individuals can have a similar pulse pressure (PP) but different levels of systolic blood pressure (SBP), although the underlying mechanisms have not been described. We hypothesized that, for a given level of PP, differences in SBP relate to peripheral vascular resistance (PVR); and we tested this hypothesis in a large cohort of healthy young adults. Methods and Results Demographic, biochemical, and hemodynamic data from 3103 subjects were available for the current analyses. In both men and women, for a given level of PP, higher SBP was associated with significantly higher body weight, body mass index, heart rate, and PVR (
Identifiants
pubmed: 33044913
doi: 10.1161/JAHA.119.014375
pmc: PMC7428627
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e014375Subventions
Organisme : British Heart Foundation
ID : PG03/050/15366
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/06/005
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Investigateurs
Samantha Benedict
(S)
Zahid Dhakam
(Z)
Lisa Day
(L)
Maggie Munnery
(M)
Pawan Pusalkar
(P)
Christopher Retallick
(C)
Ramsey Sabit
(R)
James Sharman
(J)
Jane Smith
(J)
Jean Woodcock-Smith
(J)
Edna Thomas
(E)
Sharon Wallace
(S)
Références
Hypertension. 1999 Oct;34(4 Pt 2):808-12
pubmed: 10523365
J Hypertens Suppl. 1986 Dec;4(5):S378-80
pubmed: 3471911
Circulation. 2008 Jun 24;117(25):3171-80
pubmed: 18559702
Circulation. 1997 Jul 1;96(1):308-15
pubmed: 9236450
Hypertension. 2005 Jul;46(1):221-6
pubmed: 15867140
J Hypertens. 2016 Feb;34(2):290-7
pubmed: 26682781
Am J Hypertens. 2009 May;22(5):531-7
pubmed: 19229194
J Hypertens. 1991 Jan;9(1):77-84
pubmed: 1848264
Circulation. 1963 Apr;27(4 Pt 1):520-9
pubmed: 14022748
J Am Heart Assoc. 2020 Feb 18;9(4):e015123
pubmed: 32063122
Acta Physiol Scand. 1958 Dec 15;44(3-4):255-72
pubmed: 13617022
Am J Physiol. 1998 Feb;274(2):H500-5
pubmed: 9486253
Circulation. 2003 Sep 30;108(13):1592-8
pubmed: 12975261
Hypertension. 1998 Sep;32(3):556-9
pubmed: 9740625
Hypertens Res. 2019 Jun;42(6):834-844
pubmed: 30560890
Clin Sci (Lond). 2002 Feb;102(2):247-52
pubmed: 11834145
Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):372
pubmed: 15556929
J Hum Hypertens. 2003 Feb;17(2):93-100
pubmed: 12574786
J Clin Monit Comput. 2004 Dec;18(5-6):373-8
pubmed: 15957629
J Appl Physiol (1985). 1994 Jun;76(6):2832-9
pubmed: 7928918
Br J Clin Pharmacol. 2001 Dec;52(6):631-46
pubmed: 11736874
J Clin Invest. 1997 Apr 15;99(8):1873-9
pubmed: 9109431
Epidemiology. 2012 Mar;23(2):203-11
pubmed: 22249241
Vasc Med. 2000;5(3):141-5
pubmed: 11104296
J Am Coll Cardiol. 2015 Feb 3;65(4):327-335
pubmed: 25634830