The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering.
Activation
Cell adhesion
Clustering
Integrin
Molecular dynamics
Talin
Journal
Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457
Informations de publication
Date de publication:
12 10 2020
12 10 2020
Historique:
received:
12
09
2019
accepted:
31
07
2020
entrez:
13
10
2020
pubmed:
14
10
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Integrin activation and clustering by talin are early steps of cell adhesion. Membrane-bound talin head domain and kindlin bind to the β integrin cytoplasmic tail, cooperating to activate the heterodimeric integrin, and the talin head domain induces integrin clustering in the presence of Mn
Identifiants
pubmed: 33046605
pii: 133/19/jcs239202
doi: 10.1242/jcs.239202
pmc: PMC10679385
pii:
doi:
Substances chimiques
Integrin beta3
0
Talin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM119560
Pays : United States
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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