Undecanoic Acid, Lauric Acid, and N-Tridecanoic Acid Inhibit
E. coli
biofilms
medium-chain saturated fatty acids
persister cells
Journal
Journal of microbiology and biotechnology
ISSN: 1738-8872
Titre abrégé: J Microbiol Biotechnol
Pays: Korea (South)
ID NLM: 9431852
Informations de publication
Date de publication:
28 Jan 2021
28 Jan 2021
Historique:
received:
15
08
2020
revised:
09
10
2020
accepted:
12
10
2020
pubmed:
14
10
2020
medline:
7
7
2021
entrez:
13
10
2020
Statut:
ppublish
Résumé
Persister cell formation and biofilms of pathogens are extensively involved in the development of chronic infectious diseases. Eradicating persister cells is challenging, owing to their tolerance to conventional antibiotics, which cannot kill cells in a metabolically dormant state. A high frequency of persisters in biofilms makes inactivating biofilm cells more difficult, because the biofilm matrix inhibits antibiotic penetration. Fatty acids may be promising candidates as antipersister or antibiofilm agents, because some fatty acids exhibit antimicrobial effects. We previously reported that fatty acid ethyl esters effectively inhibit
Identifiants
pubmed: 33046677
pii: jmb.2008.08027
doi: 10.4014/jmb.2008.08027
pmc: PMC8513074
mid: NIHMS1743623
doi:
Substances chimiques
Anti-Bacterial Agents
0
Fatty Acids
0
Lauric Acids
0
lauric acid
1160N9NU9U
undecanoic acid
138ON3IIQG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
130-136Subventions
Organisme : NIAID NIH HHS
ID : R15 AI130988
Pays : United States
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